The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Amarin Spons ADR 023111206 14,638 8,087,486 SH   DFND   8,087,486 0 0
Anthera Common 03674U102 1,467 437,994 SH   DFND   437,994 0 0
Cempra Common 15130J109 8,243 714,285 SH   DFND   714,285 0 0
Dicerna Common 253031108 33,314 1,182,196 SH   DFND   1,182,196 0 0
GW Pharma (US) Spons ADR 36197T103 6,067 102,200 SH   DFND   102,200 0 0
Hyperion Common 44915N101 1,612 62,500 SH   DFND   62,500 0 0
Oncogenex Pharma Common 68230A106 7,088 603,740 SH   DFND   603,740 0 0
Portola Common 737010108 32,140 1,240,912 SH   DFND 1 1,240,912 0 0
Prosensa Common N71546100 34,860 6,213,924 SH   DFND 1 6,213,924 0 0
Regulus Common 75915K101 2,943 327,350 SH   DFND   327,350 0 0
Supernus Common 868459108 32,148 3,600,000 SH   DFND 1 3,600,000 0 0
Zalicus Common 98887C105 96 78,966 SH   DFND   78,966 0 0
Zogenix Common 98978L105 6,632 2,335,218 SH   DFND 1 2,335,218 0 0