Consolidated Statements of Operations - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenues:
Collaborative licensing and milestone revenue	$ 125	$ 0	$ 0
Total revenues	541,533	429,647	421,026
Operating expenses:
Cost of goods sold	140,255	117,328	106,712
Research and development	55,545	59,421	72,119
Selling, general and administrative	199,345	193,516	200,782
Amortization of acquired intangible assets	13,553	7,866	5,703
Acquisition-related charges, product discontinuation and other	42,911	5,166	25,230
Total operating expenses	451,609	383,297	410,546
Income from operations	89,924	46,350	10,480
Other (expense) income:
Interest income	896	4,629	7,376
Interest expense	(31,750)	(25,671)	(23,628)
Loss on early extinguishment of debt	0	(8,071)	0
Other, net	(2,666)	2,852	(4,976)
Total other expense, net	(33,520)	(26,261)	(21,228)
Income (loss) before income taxes	56,404	20,089	(10,748)
Income tax (expense) benefit	(14,424)	125,434	(268)
Net income (loss)	$ 41,980	$ 145,523	$ (11,016)
Net income (loss) per share:
Basic net income (loss) per common share (in USD per share)	$ 0.95	$ 3.41	$ (0.27)
Diluted net income (loss) per common share (in USD per share)	$ 0.92	$ 3.33	$ (0.27)
Weighted average common shares outstanding:
Basic (in shares)	44,262,000	42,671,000	41,513,000
Diluted (in shares)	45,630,000	43,682,000	41,513,000
Net product sales
Revenues:
Revenues	$ 538,966	$ 426,614	$ 418,926
Royalty revenue
Revenues:
Revenues	$ 2,442	$ 3,033	$ 2,100