X0306 4 2022-06-06 0 0001396814 Pacira BioSciences, Inc. PCRX 0001296965 Williams Kristen Marie C/O PACIRA BIOSCIENCES, INC. 5401 WEST KENNEDY BOULEVARD, SUITE 890 TAMPA FL 33609 0 1 0 0 Chief Administrative Officer Common Stock 2022-06-06 4 S 0 3969 61.374 D 18299 D Common Stock 2022-06-07 4 S 0 4649 59.51 D 13650 D Common Stock 2022-06-08 4 A 0 9900 0.00 A 23550 D Stock Option (Right to Buy) 59.39 2022-06-08 4 A 0 24800 0.00 A 2032-06-08 Common Stock 24800 24800 D Represents shares sold by the reporting person to cover tax obligations upon the vesting of restricted stock units. The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the reporting person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934. Represents restricted stock units that vest in four equal annual installments beginning on June 3, 2023, provided that the reporting person remains in continuous service with the issuer as of each vesting date. Each restricted stock unit represents the contingent right to receive one share of the issuer's common stock. The stock option vests and becomes exercisable as to 25% of the option shares on the first anniversary of the grant date, and vests as to the remaining shares in successive equal quarterly installments over the subsequent three years, provided that the reporting person remains in continuous service with the issuer as of each vesting date. /s/ Kristen Williams 2022-06-08