X0306 4 2022-02-28 0 0001396814 Pacira BioSciences, Inc. PCRX 0001184778 PACE GARY W C/O PACIRA BIOSCIENCES, INC. 5401 WEST KENNEDY BOULEVARD, SUITE 890 TAMPA FL 33609 1 0 0 0 Common Stock 2022-02-28 4 M 0 9807 11.02 A 139337 D Common Stock 2022-02-28 4 M 0 18834 11.02 A 158171 D Common Stock 2022-02-28 4 S 0 28641 66.83 D 129530 D Common Stock 2022-03-01 4 M 0 193 11.02 A 129723 D Common Stock 2022-03-01 4 M 0 1166 11.02 A 130889 D Common Stock 2022-03-01 4 S 0 1359 67.75 D 129530 D Stock Option (Right to Buy) 11.02 2022-02-28 4 M 0 9807 0.00 D 2022-04-02 Common Stock 9807 193 D Stock Option (Right to Buy) 11.02 2022-02-28 4 M 0 18834 0.00 D 2022-04-02 Common Stock 18834 1166 D Stock Option (Right to Buy) 11.02 2022-03-01 4 M 0 193 0.00 D 2022-04-02 Common Stock 193 0 D Stock Option (Right to Buy) 11.02 2022-03-01 4 M 0 1166 0.00 D 2022-04-02 Common Stock 1166 0 D he price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $66.750 to $67.155, inclusive. The reporting person undertakes to provide to the issuer, any shareholder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote. The stock option vested and became exercisable in twelve equal monthly installments, with the first installment being on May 3, 2012. The option vested and became exercisable as to 25% of the option shares on April 3, 2013 and as to the remaining shares in successive equal monthly installments for the subsequent 36 months. /s/ Kristen Williams, Attorney-in-Fact 2022-03-01