X0306 4 2021-02-02 0 0001396814 Pacira BioSciences, Inc. PCRX 0001204788 STACK DAVID M C/O PACIRA BIOSCIENCES, INC. 5 SYLVAN WAY, SUITE 300 PARSIPPANY NJ 07054 1 1 0 0 CEO and Chairman Common Stock 2021-02-02 4 M 0 21250 10.81 A 97311 D Common Stock 2021-02-02 4 S 0 2900 68.41 D 94411 D Common Stock 2021-02-02 4 S 0 14250 69.38 D 80161 D Common Stock 2021-02-02 4 S 0 4100 70.20 D 76061 D Common Stock 2021-02-03 4 M 0 21250 10.81 A 97311 D Common Stock 2021-02-03 4 S 0 6900 70.78 D 90411 D Common Stock 2021-02-03 4 S 0 14350 71.42 D 76061 D Common Stock 98353 I By Three Colleens Investment, LLC Common Stock 18596 I By Stack Schroon Mohawk FLP Common Stock 315 I By LCK Investment LLC Stock Option (Right to Buy) 10.81 2021-02-02 4 M 0 21250 0.00 D 2022-06-05 Common Stock 21250 152420 D Stock Option (Right to Buy) 10.81 2021-02-03 4 M 0 21250 0.00 D 2022-06-05 Common Stock 21250 131170 D The option exercises and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the reporting person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934. Includes 144 shares of common stock acquired under the issuer's employee stock purchase plan in December 2020. Reflects the transfer of 98,353 shares of common stock previously held directly by the reporting person to Three Colleens Investment, LLC, an entity through which the reporting person holds such shares of common stock indirectly. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $67.83 to $68.82, inclusive. The reporting person undertakes to provide to the issuer, any shareholder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes 4 through 8. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $68.83 to $69.815, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $69.83 to $70.795, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $69.99 to $70.985, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $70.99 to $71.85, inclusive. Mr. Stack and his wife are the owners of each of Three Colleens Investment, LLC and LCK Investment LLC. Mr. Stack is the general partner of Stack Schroon Mohawk FLP. The option vested and became exercisable as to 25% of the option shares on June 5, 2013 and as to the remaining shares in successive equal monthly installments for the subsequent 36 months. /s/ Kristen Williams, Attorney-in-Fact 2021-02-04