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Stock-Based Compensation (Tables)
3 Months Ended
Mar. 31, 2022
Equity [Abstract]  
Schedule of Restricted Common Stock And Non-qualified Stock Option Activity
Restricted common stock and non-qualified stock option activity during the three months ended March 31, 2022, consisted of the following:

Period
Total Number of Restricted Shares Issued
 
 Total Number of Non-qualified Stock Options Granted Vesting Periods Years
January 1, 2022 to March 31, 2022(340,502)(1)— N/A
Total(340,502)— 
Schedule of Stock-based Compensation Expense
The following table sets forth the Company’s stock-based compensation expense for the periods indicated (in thousands):
 Three Months Ended March 31,
 20222021
Equity Classified Awards
Stock options
Cost of goods sold$85 $— 
Research and development51 — 
Selling, general and administrative1,444 — 
Preliminary stage projects
Other94 
Restricted stock
Cost of goods sold108 — 
Research and development58 125 
Selling, general and administrative2,050 437 
Preliminary stage projects11 
Other138 
Total equity classified awards4,044 562 
Liability Classified Awards
Restricted stock
Selling, general and administrative193 — 
Stock appreciation rights
Research and development— 348 
Selling, general and administrative21 15 
Total liability classified awards214 363 
Total stock-based compensation$4,258 $925 
Schedule Stock Option Award Activity Stock option activity under the Company’s stock incentive plans and changes during the three months ended March 31, 2022, were as follows:
Number of Options
Weighted-Average Exercise Price (1)Weighted-Average Remaining Contractual Term (years)Aggregate Intrinsic Value
Options outstanding at December 31, 20214,739,940 $5.14 9.6$— 
Granted— 
Canceled or forfeited(174,187)$5.63 
Exercised— 
Options outstanding at March 31, 20224,565,753 $5.12 9.4$— 
Options exercisable at March 31, 20221,520 $427.69 4.4$— 
(1) Exercise price of options outstanding range from $4 to $99,300 as of March 31, 2022. The higher range is related to historical stock reverse splits.
Schedule of Non-vested Restricted Stock Awards Non-vested restricted stock awards and the changes during the three months ended March 31, 2022, were as follows:
 
Number of Shares
Weighted-Average Grant-Date Fair Value
Outstanding at December 31, 20217,094,785 $3.93 
Granted— $— 
Exercised(165,870)$1.09 
Canceled or forfeited(174,268)$4.53 
Vested(364)$2.30 
Non-vested at March 31, 20226,754,283 $4.01