Note 16 - Stock-based Compensation (Tables)

12 Months Ended

Dec. 31, 2021

Notes Tables

Share-based Payment Arrangement, Cost by Plan [Table Text Block]

	Year Ended December 31,
	2021		2020			2019
Equity Classified Awards
Stock options
Cost of goods sold	$	16	$	—		$	—
Research and development		681		—			—
Selling, general and administrative		1,990		—			—
Restricted stock awards
Cost of goods sold		27		—			—
Research and development		1,345		481			228
Selling, general and administrative		3,641		1,620			993
Total equity classified awards		7,700		2,101			1,221
Liability Classified Awards
Restricted stock
Selling, general and administrative		2,165		—			—
Stock appreciation rights
Research and Development		9		137			66
Selling, general and administrative		—		(113	)		62
Total liability classified awards		2,174		24			128
Total stock-based compensation	$	9,874	$	2,125		$	1,349

Share-based Payment Arrangement, Option, Activity [Table Text Block]

						Weighted-
						Average
				Weighted-		Remaining
				Average		Contractual		Aggregate
	Number of			Exercise		Term		Intrinsic
	Options			Price (1)		(years)		Value
Options outstanding at December 31, 2020		1,552		$	556.13		5.6	$	—
Granted		4,762,004		$	4.63
Canceled or forfeited		(17,188	)	$	5,693.43
Exercised		—		$	—
Options outstanding at December 31, 2021		4,746,368		$	5.11		9.6	$	—
Options exercisable at December 31, 2021		1,515		$	429.54		4.6	$	—
Options vested and expected to vest at December 31, 2021		4,746,368		$	5.11		9.6	$	—

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

	Grant Date (1)
Exercise price	$	4.42		to	$	5.38
Risk-free interest rate		0.87	%	to		1.36	%
Expected dividend yield		—		to		—
Expected volatility factor		141	%	to		142	%
Expected option life (years)		5.75		to		6.0
Weighted-average fair value	$	4.06			$	4.95

Schedule of Nonvested Share Activity [Table Text Block]

				Weighted-
				Average
	Number of			Grant-Date
	Shares			Fair Value
Non-vested at December 31, 2020		4,701,556		$	0.79
Granted		4,955,693		$	5.08
Vested		(2,625,259	)	$	1.04
Canceled or forfeited		(149,488	)	$	1.31
Non-vested at December 31, 2021		6,882,502		$	3.77