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Note 12 - Embedded Derivatives (Tables)
12 Months Ended
Dec. 31, 2021
Notes Tables  
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
  Issuance Date Expiration Date 

 

Exercise Price as of December 31, 2021

  Shares Underlying Warrants on Issuance Date  Shares Issued Upon Warrant Exercises as of December 31, 2021  Shares Underlying Warrants as of December 31, 2021 
                     
Series K Warrants February 17, 2017 February 17, 2022 $2.00   315,986   308,860   7,126 
Series 2020-A Warrants (1) July 6, 2020 July 6, 2025 $0.60   30,000,000   29,909,392   90,608 
                     
           30,315,986   30,218,252   97,734 
Exercise of Warrants [Table Text Block]
  

Common Stock Issued

  

Proceeds

 
         
Series K Warrants  200  $1 

Series 2020-C Warrants

  1,866,558   1,120 
         
   1,866,758  $1,121 
  

Common Stock Issued

  

Proceeds

 
         

Series 2020-A Warrants

  28,042,834  $16,826 

Series 2020-B Warrants

  9,103,334   91 

Series 2020-C Warrants

  16,532,232   165 
         
   53,678,400  $17,082