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Note 2 - Summary of Significant Accounting Policies (Tables)
12 Months Ended
Dec. 31, 2021
Notes Tables  
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
 

Year Ended December 31,

 
 2021 2020 

2019

 
       

Warrants to purchase common stock - liability classified

7,126 56,735 54,989 

Warrants to purchase common stock - equity classified

90,608 1,957,166  
Convertible 2020 Notes  974,139 

Outstanding options to purchase common stock

4,746,368 1,552 1,561 

Stock appreciation rights

67,739 67,739 67,739 
       

Total

4,911,841 2,083,192 1,098,428