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Note 11 - Stock-based Compensation (Tables)
 3 Months Ended
Mar. 31, 2021
Notes Tables  
Share-based Payment Arrangement, Cost by Plan [Table Text Block]
   
Three Months Ended March 31,
  
   
2021
    
2020
  
Restricted stock
                
Research and development
   $
125
     $
76
  
Selling, general and administrative    
437
      
260
  
                 
Stock appreciation rights                
Research and development    
348
      
(79
 )
Selling, general and administrative
    
15
      
(85
 )
                 
Total stock-based compensation
   $
925
     $
172
  
Share-based Payment Arrangement, Option, Activity [Table Text Block]
 
 
 
 
 
 
 
 
Weighted-
 
 
 
 
 
 
 
 
 
 
 
 
Average
 
 
 
 
 
 
 
 
 
Weighted-
 
Remaining
 
 
 
 
 
 
 
 
 
Average
 
Contractual
 
Aggregate
 
 
 
Number of
 
 
Exercise
 
Term
 
Intrinsic
 
 
 
Options
 
 
Price (1)
 
(years)
 
Value
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Options outstanding at December 31, 2020
 
1,552
 
 
$
556.13
 
5.58
 
$
—
 
Granted
 
—
 
 
$
—
 
 
 
 
 
 
Canceled or forfeited
 
(35
)
 
$
876.00
 
 
 
 
 
 
Exercised
 
—
 
 
$
—
 
 
 
 
 
 
 
 
  
 
 
 
  
 
  
 
 
  
 
Options outstanding at
March 31, 2021
 
1,517
 
 
$
548.75
 
5.36
 
$
—
 
 
 
  
 
 
 
  
 
  
 
 
  
 
Options exercisable at March 31, 2021
 
1,517
 
 
$
548.75
 
5.36
 
$
—
 
 
 
  
 
 
 
  
 
  
 
 
  
 
Options vested and expected to vest at March 31, 2021
 
1,517
  
 
$
548.75
  
5.36
 
$
—
 
Schedule of Nonvested Share Activity [Table Text Block]
 
 
 
 
 
Weighted-
 
 
 
 
 
 
Average
 
 
 
Number of
 
 
Grant-Date
 
 
 
Shares
 
 
Fair Value
 
 
 
 
 
 
 
 
 
Non-vested at December 31, 2020
 
4,701,556
  
 
$
0.79
  
Granted
 
—
  
 
$
—
 
Vested
 
—
  
 
$
—
  
Canceled or forfeited
 
(120,808
 )
 
$
0.81
 
 
 
    
 
 
  
 
Non-vested at March 31, 2021
 
4,580,748
  
 
$
0.79