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Note 11 - Stock-based Compensation
 3 Months Ended
Mar. 31, 2021
Notes to Financial Statements  
Share-based Payment Arrangement [Text Block]
11.
Stock-Based Compensation
 
Stock-Based Compensation Expense
. The Company records stock-based compensation expense during the requisite service period for share-based payment awards granted to employees and non-employees.
 
The following table sets forth the Company's stock-based compensation expense (in thousands) for the periods indicated:
 
   
Three Months Ended March 31,
  
   
2021
    
2020
  
Restricted stock
                
Research and development
   $
125
     $
76
  
Selling, general and administrative    
437
      
260
  
                 
Stock appreciation rights                
Research and development    
348
      
(79
 )
Selling, general and administrative
    
15
      
(85
 )
                 
Total stock-based compensation
   $
925
     $
172
  
 
 
Stock Option Award Activity
. Stock option activity under the Company's stock incentive plans at
March 31, 2021
and changes during the
three
months ended
March 31, 2021
were as follows:
 
 
 
 
 
 
 
 
 
Weighted-
 
 
 
 
 
 
 
 
 
 
 
 
Average
 
 
 
 
 
 
 
 
 
Weighted-
 
Remaining
 
 
 
 
 
 
 
 
 
Average
 
Contractual
 
Aggregate
 
 
 
Number of
 
 
Exercise
 
Term
 
Intrinsic
 
 
 
Options
 
 
Price (1)
 
(years)
 
Value
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Options outstanding at December 31, 2020
 
1,552
 
 
$
556.13
 
5.58
 
$
—
 
Granted
 
—
 
 
$
—
 
 
 
 
 
 
Canceled or forfeited
 
(35
)
 
$
876.00
 
 
 
 
 
 
Exercised
 
—
 
 
$
—
 
 
 
 
 
 
 
 
  
 
 
 
  
 
  
 
 
  
 
Options outstanding at
March 31, 2021
 
1,517
 
 
$
548.75
 
5.36
 
$
—
 
 
 
  
 
 
 
  
 
  
 
 
  
 
Options exercisable at March 31, 2021
 
1,517
 
 
$
548.75
 
5.36
 
$
—
 
 
 
  
 
 
 
  
 
  
 
 
  
 
Options vested and expected to vest at March 31, 2021
 
1,517
  
 
$
548.75
  
5.36
 
$
—
 
 
(
1
)  Exercise price of options outstanding range from
$20
 to
$99,300
 as of
March 31, 2021.
 
Restricted Stock
. Non-vested restricted stock awards at
March 31, 2021
and changes during the
three
months ended
March 31, 2021
were as follows:
 
 
 
 
 
 
Weighted-
 
 
 
 
 
 
Average
 
 
 
Number of
 
 
Grant-Date
 
 
 
Shares
 
 
Fair Value
 
 
 
 
 
 
 
 
 
Non-vested at December 31, 2020
 
4,701,556
  
 
$
0.79
  
Granted
 
—
  
 
$
—
 
Vested
 
—
  
 
$
—
  
Canceled or forfeited
 
(120,808
 )
 
$
0.81
 
 
 
    
 
 
  
 
Non-vested at March 31, 2021
 
4,580,748
  
 
$
0.79
  
 
The total fair value of restricted stock that vested during the
three
months ended
March 31, 2021
was
nil.
 As of
March 31, 2021,
the total unrecognized compensation expense, net of estimated forfeitures, relating to restricted stock awards was
$1.9
 million, which is expected to be recognized over the remaining weighted-average period of approximately
1.1
 years.