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Note 12 - Income Taxes - Reconciling Items from Income Tax Computed at the Statutory Federal Rate (Details)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Federal income tax at statutory rate 21.00% 35.00% 35.00%
State income taxes, net of federal benefits 6.20% 7.50% 2.90%
Research and other credits 0.00% 0.00% (5.80%)
Impact of change in statutory tax rates (8.80%) (183.80%) 0.00%
Permanent deductions (3.70%) 7.50% (18.00%)
Valuation allowance (14.70%) 133.80% (14.10%)
Effective tax rate 0.00% 0.00% 0.00%