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Note 8 - Derivative Warrant Liability (Tables)
12 Months Ended
Dec. 31, 2018
Notes Tables  
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
 
Issuance
Date
 
Expiration
Date
 
Exercise
Price as of
December 31,
2018
     
Shares
Underlying
Warrants on
Issuance Date
   
Shares Issued
upon Warrant
Exercises as of
December 31,
2018
   
Shares
Underlying
Warrants
Outstanding as of
December 31,
2018
(1)
 
2014 Warrants
08/05/2014
 
08/05/2019
  $
65.50
       
2,500
     
1,526
     
974
 
Series A Warrants
02/03/2015
 
02/03/2020
  $
3.80
       
5,542
     
5,222
     
320
 
Series C Warrants
05/19/2015
 
05/19/2020
  $
53.43
       
1,075
     
     
1,075
 
Series D Warrants
12/11/2015
 
12/11/2020
  $
40.00
       
25,125
     
25,078
     
47
 
Series F Warrants
04/01/2016
 
04/01/2021
  $
40.00
       
25,733
     
11,692
     
14,041
 
Series I Warrants
09/13/2016
 
09/13/2021
  $
220.00
       
35,650
     
     
35,650
 
Series K Warrants
02/17/2017
 
2/17/2022
  $
3.80
       
312,516
     
308,660
     
3,856
 
 
 
 
 
   
 
       
408,141
     
352,178
     
55,963
 
Schedule of Warrant Exercises [Table Text Block]
   
Twelve Months Ended
December 31, 201
8
 
   
Common Stock
Issued
   
Proceeds
 
Series A Warrants
   
251
     
1,054
 
Series K Warrants
   
300,660
     
1,262,712
 
     
300,911
    $
1,263,766