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Note 11 - Stock-based Compensation (Tables)
 6 Months Ended
Jun. 30, 2018
Notes Tables  
Schedule of Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Table Text Block]
   
Three Months Ended June 30,
    
Six Months Ended June 30,
  
   
2018
    
2017
    
2018
    
2017
  
Stock options and employee stock purchase plan awards
                                
Research and development
   $
9
     $
9
     $
18
     $
18
  
Selling, general and administrative
    
11
      
31
      
41
      
61
  
                                 
Restricted stock awards
                                
Research and development
    
-
      
1
      
-
      
13
  
Selling, general and administrative
    
-
      
-
      
-
      
17
  
                                 
Restricted stock units
                                
Research and development
    
17
      
17
      
34
      
35
  
Selling, general and administrative
    
17
      
39
      
58
      
81
  
                                 
Stock appreciation rights                                
Research and development    
-
      
-
      
-
      
-
  
Selling, general and administrative    
86
      
-
      
86
      
-
  
Total stock-based compensation
   $
140
     $
97
     $
237
     $
225