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Note 11 - Stock-based Compensation
 6 Months Ended
Jun. 30, 2018
Notes to Financial Statements  
Disclosure of Compensation Related Costs, Share-based Payments [Text Block]
11.
Stock-Based Compensation
 
The Company records stock-based compensation expense during the requisite service period for share-based payment awards granted to employees and non-employees.
 
The following table sets forth the Company’s stock-based compensation expense (in thousands) for the periods indicated.
 
   
Three Months Ended June 30,
    
Six Months Ended June 30,
  
   
2018
    
2017
    
2018
    
2017
  
Stock options and employee stock purchase plan awards
                                
Research and development
   $
9
     $
9
     $
18
     $
18
  
Selling, general and administrative
    
11
      
31
      
41
      
61
  
                                 
Restricted stock awards
                                
Research and development
    
-
      
1
      
-
      
13
  
Selling, general and administrative
    
-
      
-
      
-
      
17
  
                                 
Restricted stock units
                                
Research and development
    
17
      
17
      
34
      
35
  
Selling, general and administrative
    
17
      
39
      
58
      
81
  
                                 
Stock appreciation rights                                
Research and development    
-
      
-
      
-
      
-
  
Selling, general and administrative    
86
      
-
      
86
      
-
  
Total stock-based compensation
   $
140
     $
97
     $
237
     $
225