X0306 4 2016-10-25 0 0001390478 Galena Biopharma, Inc. GALE 0001311726 Knapp Thomas J C/O GALENA BIOPHARMA, INC. 2000 CROW CANYON PL., SUITE 380 SAN RAMON CA 94583 0 1 0 0 General Counsel Stock Option (right to buy) 0.29 2016-10-25 4 A 0 102000 0 A 2026-10-25 Common Stock 102000 102000 D Granted pursuant to the Issuer's 2016 Incentive Plan. The Reporting Person obtained the securities pursuant to an Employment Agreement Amendment dated October 1, 2016. The securities were convertible into common stock at the rate of 1 share of common stock for each 1 stock option share, or an aggregate of 102,000 shares of common stock (pre-reverse stock split). The securities were converted into 5,100 stock options at a price of $5.744 per share (post-reverse split) as of November 14, 2016. This stock option vests in equal monthly installments beginning November 25, 2016 and ending March 31, 2017. Thomas J. Knapp 2016-12-20