The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2SEVENTY BIO INC COMMON STOCK 901384107   2,120,505 429,252 SH   SOLE   429,252 0 0
ACCURAY INC COM 004397105   2,188,021 1,222,358 SH   SOLE   1,222,358 0 0
ADC THERAPEUTICS SA SHS H0036K147   315,954 224,081 SH   SOLE   224,081 0 0
ADICET BIO INC COM 007002108   453,000 600,000 SH   SOLE   600,000 0 0
ALECTOR INC COM 014442107   1,122,901 912,928 SH   SOLE   912,928 0 0
ALIGN TECHNOLOGY INC COM 016255101   1,747,460 11,000 SH   SOLE   11,000 0 0
ALKERMES PLC SHS G01767105   3,110,484 94,200 SH   SOLE   94,200 0 0
ALLOGENE THERAPEUTICS INC COM 019770106   2,014,972 1,380,118 SH   SOLE   1,380,118 0 0
APREA THERAPEUTICS INC COM NEW 03836J201   279,835 137,174 SH   SOLE   137,174 0 0
AQUESTIVE THERAPEUTICS INC COM 03843E104   411,800 142,000 SH   SOLE   142,000 0 0
ARCUS BIOSCIENCES INC COM 03969F109   4,907,239 625,126 SH   SOLE   625,126 0 0
ARS PHARMACEUTICALS INC COM 82835W108   1,198,748 95,290 SH   SOLE   95,290 0 0
ASCENDIS PHARMA A/S NOTE 2.250% 4/0 04351PAD3   4,710,000 4,000,000 PRN   SOLE   4,000,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   12,530,832 80,398 SH   SOLE   80,398 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   1,680,899 314,775 SH   SOLE   314,775 0 0
ATRICURE INC COM 04963C209   19,106,727 592,273 SH   SOLE   592,273 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   909,334 586,667 SH   SOLE   586,667 0 0
AXOGEN INC COM 05463X106   12,594,467 680,782 SH   SOLE   680,782 0 0
BICARA THERAPEUTICS INC COM 055477103   2,762,373 212,001 SH   SOLE   212,001 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108   685,984 80,799 SH   SOLE   80,799 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   4,186,913 558,255 SH   SOLE   558,255 0 0
BIOHAVEN LTD COM G1110E107   5,294,449 220,235 SH   SOLE   220,235 0 0
BIOMX INC COM NEW 09090D301   222,911 401,136 SH   SOLE   401,136 0 0
BIONTECH SE SPONSORED ADS 09075V102   956,130 10,500 SH   SOLE   10,500 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105   217,000 140,000 SH   SOLE   140,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109   13,476,798 152,263 SH   SOLE   152,263 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106   1,482,368 156,533 SH   SOLE   156,533 0 0
CARDIFF ONCOLOGY INC COM 14147L108   471,000 150,000 SH   SOLE   150,000 0 0
CENTURY THERAPEUTICS INC COM 15673T100   811,215 1,704,232 SH   SOLE   1,704,232 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101   2,033,592 711,046 SH   SOLE   711,046 0 0
COMPUGEN LTD ORD M25722105   397,707 272,402 SH   SOLE   272,402 0 0
CYTOKINETICS INC COM NEW 23282W605   15,999,639 398,100 SH   SOLE   398,100 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   5,799,709 731,363 SH   SOLE   731,363 0 0
DENALI THERAPEUTICS INC COM 24823R105   1,738,801 127,900 SH   SOLE   127,900 0 0
DEXCOM INC COM 252131107   4,476,546 65,552 SH   SOLE   65,552 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   4,029,080 183,140 SH   SOLE   183,140 0 0
ERASCA INC COM 29479A108   465,800 340,000 SH   SOLE   340,000 0 0
FOGHORN THERAPEUTICS INC COM 344174107   1,112,345 304,752 SH   SOLE   304,752 0 0
GALAPAGOS NV SPON ADR 36315X101   3,269,996 130,175 SH   SOLE   130,175 0 0
GOSSAMER BIO INC COM 38341P102   998,639 907,854 SH   SOLE   907,854 0 0
IDEAYA BIOSCIENCES INC COM 45166A102   9,653,225 589,330 SH   SOLE   589,330 0 0
IMMATICS NV SHS N44445109   1,104,950 245,000 SH   SOLE   245,000 0 0
IMMUNOVANT INC COM 45258J102   2,905,232 169,996 SH   SOLE   169,996 0 0
INFLARX NV COM N44821101   459,000 450,000 SH   SOLE   450,000 0 0
INOGEN INC COM 45780L104   3,266,003 458,065 SH   SOLE   458,065 0 0
INSULET CORP COM 45784P101   3,125,059 11,900 SH   SOLE   11,900 0 0
ISHARES NASDAQ BIOTECH INDX ETF 464287556   13,109,750 102,500 SH   SOLE   102,500 0 0
ITEOS THERAPEUTICS INC COM 46565G104   1,273,682 213,347 SH   SOLE   213,347 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103   8,682,223 752,359 SH   SOLE   752,359 0 0
KEROS THERAPEUTICS INC COM 492327101   1,327,920 130,316 SH   SOLE   130,316 0 0
KORRO BIO INC COM 500946108   819,767 47,086 SH   SOLE   47,086 0 0
KURA ONCOLOGY INC COM 50127T109   3,058,229 463,368 SH   SOLE   463,368 0 0
LARIMAR THERAPEUTICS INC COM 517125100   798,583 371,434 SH   SOLE   371,434 0 0
LEXEO THERAPEUTICS INC COM 52886X107   1,311,948 378,083 SH   SOLE   378,083 0 0
LINEAGE CELL THERAPEUTICS IN COM 53566P109   1,134,136 2,511,374 SH   SOLE   2,511,374 0 0
MEDIWOUND LTD SHS NEW M68830112   1,000,714 64,479 SH   SOLE   64,479 0 0
MERUS N V COM N5749R100   19,437,330 461,804 SH   SOLE   461,804 0 0
MINERALYS THERAPEUTICS INC COM 603170101   4,910,096 309,200 SH   SOLE   309,200 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   7,920,619 71,615 SH   SOLE   71,615 0 0
NEUROGENE INC COM 64135M105   603,065 51,500 SH   SOLE   51,500 0 0
NEVRO CORP COM 64157F103   221,920 38,000 SH   SOLE   38,000 0 0
ORIC PHARMACEUTICALS INC COM 68622P109   1,350,360 242,000 SH   SOLE   242,000 0 0
PALVELLA THERAPEUTICS INC COM 697947109   1,213,311 43,348 SH   SOLE   43,348 0 0
POLYPID LTD COM M8001Q126   789,350 291,273 SH   SOLE   291,273 0 0
PROQR THERAPEUTICS N V SHS EURO N71542109   2,084,856 1,567,561 SH   SOLE   1,567,561 0 0
REGULUS THERAPEUTICS INC COM 75915K309   1,482,558 847,176 SH   SOLE   847,176 0 0
REVOLUTION MEDICINES INC COM 76155X100   23,202,383 656,176 SH   SOLE   656,176 0 0
SAGE THERAPEUTICS INC COM 78667J108   860,190 108,200 SH   SOLE   108,200 0 0
SPDR S&P BIOTECH ETF ETF 78464A870   32,805,356 404,505 SH   SOLE   404,505 0 0
SPERO THERAPEUTICS INC COM 84833T103   90,000 125,000 SH   SOLE   125,000 0 0
STEREOTAXIS INC COM NEW 85916J409   24,077,775 13,680,554 SH   SOLE   13,680,554 0 0
STOKE THERAPEUTICS INC COM 86150R107   2,952,587 443,998 SH   SOLE   443,998 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106   1,021,290 59,000 SH   SOLE   59,000 0 0
SUTRO BIOPHARMA INC COM 869367102   284,364 437,079 SH   SOLE   437,079 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   6,689,207 544,502 SH   SOLE   544,502 0 0
TANDEM DIABETES CARE INC COM NEW 875372203   5,637,025 294,208 SH   SOLE   294,208 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106   726,275 522,500 SH   SOLE   522,500 0 0
TELA BIO INC COM 872381108   1,758,055 1,441,029 SH   SOLE   1,441,029 0 0
TENAYA THERAPEUTICS INC COM 87990A106   26,977 47,319 SH   SOLE   47,319 0 0
UROGEN PHARMA LTD COM M96088105   5,447,216 492,515 SH   SOLE   492,515 0 0
VIKING THERAPEUTICS INC COM 92686J106   1,558,061 64,516 SH   SOLE   64,516 0 0
VYNE THERAPEUTICS INC COM 92941V308   1,005,043 636,103 SH   SOLE   636,103 0 0
XENON PHARMACEUTICALS INC COM 98420N105   9,183,943 273,739 SH   SOLE   273,739 0 0