The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 2,469 766,774 SH   SOLE 766,774 0 0
ACCURAY INC COM 004397105 1,846 941,800 SH   SOLE 941,800 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 597 351,064 SH   SOLE 351,064 0 0
ADICET BIO INC COM 007002108 13,662 935,766 SH   SOLE 935,766 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 2,168 289,040 SH   SOLE 289,040 0 0
AERIE PHARMACEUTICALS INC NOTE 1.500%10/0 00771VAB4 1,292 1,500,000 PRN   SOLE 1,500,000 0 0
AFFIMED N V COM N01045108 1,901 686,282 SH   SOLE 686,282 0 0
ALECTOR INC COM 014442107 5,613 552,438 SH   SOLE 552,438 0 0
ANNEXON INC COM 03589W102 154 40,796 SH   SOLE 40,796 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 4,383 96,935 SH   SOLE 96,935 0 0
ARCUS BIOSCIENCES INC COM 03969F109 4,757 187,717 SH   SOLE 187,717 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 12,941 139,212 SH   SOLE 139,212 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 170 343,720 SH   SOLE 343,720 0 0
ATRICURE INC COM 04963C209 2,943 72,029 SH   SOLE 72,029 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 1,404 496,150 SH   SOLE 496,150 0 0
AXOGEN INC COM 05463X106 2,720 332,103 SH   SOLE 332,103 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 2,202 131,200 SH   SOLE 131,200 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 16,043 110,100 SH   SOLE 110,100 0 0
BIOMEA FUSION INC COM 09077A106 1,640 136,935 SH   SOLE 136,935 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 771 313,600 SH   SOLE 313,600 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 13,197 261,280 SH   SOLE 261,280 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106 966 200,000 SH   SOLE 200,000 0 0
CARDIOVASCULAR SYS INC COM 141619106 4,121 286,988 SH   SOLE 286,988 0 0
CENTURY THERAPEUTICS INC COM 15673T100 3,993 475,367 SH   SOLE 475,367 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 810 74,890 SH   SOLE 74,890 0 0
COMPASS THERAPEUTICS INC COM 20454B104 525 198,094 SH   SOLE 198,094 0 0
COMPUGEN LTD ORD M25722105 380 205,202 SH   SOLE 205,202 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 218 250,000 SH   SOLE 250,000 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 5,273 1,787,569 SH   SOLE 1,787,569 0 0
CYTOKINETICS INC COM NEW 23282W605 8,310 211,495 SH   SOLE 211,495 0 0
DEXCOM INC COM 252131107 5,407 72,552 SH   SOLE 72,552 0 0
DICE THERAPEUTICS INC COM 23345J104 2,435 156,904 SH   SOLE 156,904 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 5,540 695,959 SH   SOLE 695,959 0 0
FATE THERAPEUTICS INC COM 31189P102 13,652 550,940 SH   SOLE 550,940 0 0
FIELD TRIP HEALTH LTD COM 31656R102 1,600 1,904,141 SH   SOLE 1,904,141 0 0
F-STAR THERAPEUTICS INC COM 30315R107 3,611 576,881 SH   SOLE 576,881 0 0
GALAPAGOS NV SPON ADR 36315X101 2,381 42,675 SH   SOLE 42,675 0 0
GENFIT S A ADS 372279109 605 187,940 SH   SOLE 187,940 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 549 55,000 SH   SOLE 55,000 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 7,570 548,561 SH   SOLE 548,561 0 0
INOGEN INC COM 45780L104 363 15,000 SH   SOLE 15,000 0 0
ISHARES TR NASDAQ BIOTECH INDX ETF 464287556 12,057 102,500 SH   SOLE 102,500 0 0
ITEOS THERAPEUTICS INC COM 46565G104 2,169 105,298 SH   SOLE 105,298 0 0
IVERIC BIO INC COM 46583P102 3,872 402,476 SH   SOLE 402,476 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 2,614 265,663 SH   SOLE 265,663 0 0
KARUNA THERAPEUTICS INC COM 48576A100 7,850 62,053 SH   SOLE 62,053 0 0
KEROS THERAPEUTICS INC COM 492327101 1,078 39,000 SH   SOLE 39,000 0 0
KINNATE BIOPHARMA INC COM 49705R105 2,830 224,451 SH   SOLE 224,451 0 0
KURA ONCOLOGY INC COM 50127T109 2,160 117,829 SH   SOLE 117,829 0 0
LARIMAR THERAPEUTICS INC COM 517125100 98 49,996 SH   SOLE 49,996 0 0
LAVA THERAPEUTICS NV SHS N51517105 379 128,335 SH   SOLE 128,335 0 0
LINEAGE CELL THERAPEUTICS IN COM 53566P109 221 140,000 SH   SOLE 140,000 0 0
MACROGENICS INC COM 556099109 566 192,000 SH   SOLE 192,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 222 3,100 SH   SOLE 3,100 0 0
MASIMO CORP COM 574795100 392 3,000 SH   SOLE 3,000 0 0
MEI PHARMA INC COM NEW 55279B202 1,069 1,767,146 SH   SOLE 1,767,146 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 1,228 1,096,513 SH   SOLE 1,096,513 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1,879 406,763 SH   SOLE 406,763 0 0
MERUS N V COM N5749R100 5,952 262,891 SH   SOLE 262,891 0 0
MIRATI THERAPEUTICS INC COM 60468T105 5,344 79,600 SH   SOLE 79,600 0 0
MORPHIC HLDG INC COM 61775R105 4,242 195,467 SH   SOLE 195,467 0 0
NATUS MEDICAL INC COM 639050103 4,706 143,600 SH   SOLE 143,600 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 8,057 82,655 SH   SOLE 82,655 0 0
NEURONETICS INC COM 64131A105 1,007 313,717 SH   SOLE 313,717 0 0
NEXTCURE INC COM 65343E108 882 187,696 SH   SOLE 187,696 0 0
NGM BIOPHARMACEUTICALS INC COM 62921N105 1,380 107,653 SH   SOLE 107,653 0 0
NURIX THERAPEUTICS INC COM 67080M103 7,180 566,695 SH   SOLE 566,695 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 1,863 415,926 SH   SOLE 415,926 0 0
OTONOMY INC COM 68906L105 3,058 1,470,199 SH   SOLE 1,470,199 0 0
PARDES BIOSCIENCES INC COM 69945Q105 1,385 451,105 SH   SOLE 451,105 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 227 378,611 SH   SOLE 378,611 0 0
RADIUS HEALTH INC COM NEW 750469207 953 91,935 SH   SOLE 91,935 0 0
RADIUS HEALTH INC NOTE 3.000% 9/0 750469AA6 3,916 4,000,000 PRN   SOLE 4,000,000 0 0
REGULUS THERAPEUTICS INC COM 75915K309 1,150 555,555 SH   SOLE 555,555 0 0
REVOLUTION MEDICINES INC COM 76155X100 5,843 299,785 SH   SOLE 299,785 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 441 390,066 SH   SOLE 390,066 0 0
SAGE THERAPEUTICS INC COM 78667J108 5,824 180,306 SH   SOLE 180,306 0 0
SCYNEXIS INC COM NEW 811292200 845 454,492 SH   SOLE 454,492 0 0
SPDR SP BIOTECH ETF ETF 78464A870 45,528 613,000 SH   SOLE 613,000 0 0
STEREOTAXIS INC COM NEW 85916J409 25,172 13,680,554 SH   SOLE 13,680,554 0 0
SURFACE ONCOLOGY INC COM 86877M209 1,804 1,100,000 SH   SOLE 1,100,000 0 0
SUTRO BIOPHARMA INC COM 869367102 441 84,700 SH   SOLE 84,700 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 7,138 370,987 SH   SOLE 370,987 0 0
THESEUS PHARMACEUTICALS INC COM 88369M101 453 81,899 SH   SOLE 81,899 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 3,646 48,452 SH   SOLE 48,452 0 0
VENUS CONCEPT INC COM 92332W105 449 968,187 SH   SOLE 968,187 0 0
VIGIL NEUROSCIENCE INC COM 92673K108 257 99,754 SH   SOLE 99,754 0 0
VIKING THERAPEUTICS INC COM 92686J106 1,336 462,400 SH   SOLE 462,400 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 1,210 372,361 SH   SOLE 372,361 0 0
XENON PHARMACEUTICALS INC COM 98420N105 13,343 438,623 SH   SOLE 438,623 0 0