The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 1,222 324,053 SH   SOLE 324,053 0 0
ACCURAY INC COM 004397105 3,117 941,800 SH   SOLE 941,800 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 723 351,064 SH   SOLE 351,064 0 0
ADICET BIO INC COM 007002108 14,296 715,872 SH   SOLE 715,872 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 2,630 289,040 SH   SOLE 289,040 0 0
AERIE PHARMACEUTICALS INC NOTE 1.500%10/0 00771VAB4 1,345 1,500,000 PRN   SOLE 1,500,000 0 0
AFFIMED N V COM N01045108 2,497 571,282 SH   SOLE 571,282 0 0
ALECTOR INC COM 014442107 4,172 292,747 SH   SOLE 292,747 0 0
ANNEXON INC COM 03589W102 84 30,796 SH   SOLE 30,796 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 4,773 93,935 SH   SOLE 93,935 0 0
ARCUS BIOSCIENCES INC COM 03969F109 4,583 145,217 SH   SOLE 145,217 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 3,593 30,612 SH   SOLE 30,612 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 219 243,720 SH   SOLE 243,720 0 0
ATHIRA PHARMA INC COM 04746L104 2,173 160,983 SH   SOLE 160,983 0 0
ATRICURE INC COM 04963C209 4,730 72,029 SH   SOLE 72,029 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 2,069 496,150 SH   SOLE 496,150 0 0
AXOGEN INC COM 05463X106 2,637 332,103 SH   SOLE 332,103 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 2,334 53,200 SH   SOLE 53,200 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 9,201 77,600 SH   SOLE 77,600 0 0
BIOMEA FUSION INC COM 09077A106 1,712 383,923 SH   SOLE 383,923 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 869 313,600 SH   SOLE 313,600 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 15,732 246,280 SH   SOLE 246,280 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106 1,746 200,000 SH   SOLE 200,000 0 0
CARDIOVASCULAR SYS INC COM 141619106 6,486 286,988 SH   SOLE 286,988 0 0
CENTURY THERAPEUTICS INC COM 15673T100 3,234 256,892 SH   SOLE 256,892 0 0
COGENT BIOSCIENCES INC COM 19240Q201 1,674 223,554 SH   SOLE 223,554 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 965 74,890 SH   SOLE 74,890 0 0
COMPASS THERAPEUTICS INC COM 20454B104 269 196,091 SH   SOLE 196,091 0 0
COMPUGEN LTD ORD M25722105 419 130,202 SH   SOLE 130,202 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 5,264 1,692,569 SH   SOLE 1,692,569 0 0
CYTOKINETICS INC COM NEW 23282W605 7,785 211,495 SH   SOLE 211,495 0 0
DEXCOM INC COM 252131107 9,279 18,138 SH   SOLE 18,138 0 0
DICE THERAPEUTICS INC COM 23345J104 1,798 94,000 SH   SOLE 94,000 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 3,460 356,750 SH   SOLE 356,750 0 0
FATE THERAPEUTICS INC COM 31189P102 19,421 500,930 SH   SOLE 500,930 0 0
FIELD TRIP HEALTH LTD COM 31656R102 2,936 2,191,308 SH   SOLE 2,191,308 0 0
F-STAR THERAPEUTICS INC COM 30315R107 2,463 693,785 SH   SOLE 693,785 0 0
GALAPAGOS NV SPON ADR 36315X101 2,647 42,675 SH   SOLE 42,675 0 0
GENFIT S A ADS 372279109 752 187,940 SH   SOLE 187,940 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 1,006 55,000 SH   SOLE 55,000 0 0
HARPOON THERAPEUTICS INC COM 41358P106 523 105,163 SH   SOLE 105,163 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 5,484 490,061 SH   SOLE 490,061 0 0
IMMUNOCORE HOLDINGS PLC ADS 45258D105 1,611 53,878 SH   SOLE 53,878 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 137 120,097 SH   SOLE 120,097 0 0
INOGEN INC COM 45780L104 486 15,000 SH   SOLE 15,000 0 0
ISHARES TR NASDAQ BIOTECH INDX ETF 464287556 13,356 102,500 SH   SOLE 102,500 0 0
ITEOS THERAPEUTICS INC COM 46565G104 2,874 89,298 SH   SOLE 89,298 0 0
IVERIC BIO INC COM 46583P102 5,023 298,476 SH   SOLE 298,476 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 2,810 190,663 SH   SOLE 190,663 0 0
KARUNA THERAPEUTICS INC COM 48576A100 10,403 82,053 SH   SOLE 82,053 0 0
KINNATE BIOPHARMA INC COM 49705R105 1,668 148,151 SH   SOLE 148,151 0 0
KURA ONCOLOGY INC COM 50127T109 1,822 113,329 SH   SOLE 113,329 0 0
LARIMAR THERAPEUTICS INC COM 517125100 202 49,996 SH   SOLE 49,996 0 0
LAVA THERAPEUTICS NV SHS N51517105 613 139,332 SH   SOLE 139,332 0 0
LINEAGE CELL THERAPEUTICS IN COM 53566P109 216 140,000 SH   SOLE 140,000 0 0
MACROGENICS INC COM 556099109 1,692 192,000 SH   SOLE 192,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 304 3,100 SH   SOLE 3,100 0 0
MASIMO CORP COM 574795100 437 3,000 SH   SOLE 3,000 0 0
MEI PHARMA INC COM NEW 55279B202 1,065 1,767,146 SH   SOLE 1,767,146 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 1,363 1,216,613 SH   SOLE 1,216,613 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1,408 352,763 SH   SOLE 352,763 0 0
MERUS N V COM N5749R100 6,213 234,989 SH   SOLE 234,989 0 0
MIRATI THERAPEUTICS INC COM 60468T105 3,511 42,700 SH   SOLE 42,700 0 0
MORPHIC HLDG INC COM 61775R105 7,286 181,467 SH   SOLE 181,467 0 0
NATUS MEDICAL INC COM 639050103 5,010 190,635 SH   SOLE 190,635 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 7,843 83,655 SH   SOLE 83,655 0 0
NEURONETICS INC COM 64131A105 951 313,717 SH   SOLE 313,717 0 0
NEXTCURE INC COM 65343E108 912 187,696 SH   SOLE 187,696 0 0
NGM BIOPHARMACEUTICALS INC COM 62921N105 1,642 107,653 SH   SOLE 107,653 0 0
NURIX THERAPEUTICS INC COM 67080M103 7,612 543,344 SH   SOLE 543,344 0 0
OTONOMY INC COM 68906L105 3,594 1,497,514 SH   SOLE 1,497,514 0 0
PARDES BIOSCIENCES INC COM 69945Q105 3,041 421,157 SH   SOLE 421,157 0 0
PHARVARIS N V COM N69605108 628 34,615 SH   SOLE 34,615 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 500 378,611 SH   SOLE 378,611 0 0
RADIUS HEALTH INC COM NEW 750469207 1,695 191,978 SH   SOLE 191,978 0 0
RADIUS HEALTH INC NOTE 3.000% 9/0 750469AA6 3,891 4,000,000 PRN   SOLE 4,000,000 0 0
REGULUS THERAPEUTICS INC COM NEW 75915K200 1,656 5,555,555 SH   SOLE 5,555,555 0 0
REVOLUTION MEDICINES INC COM 76155X100 5,921 232,101 SH   SOLE 232,101 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 2,679 896,100 SH   SOLE 896,100 0 0
SAGE THERAPEUTICS INC COM 78667J108 5,968 180,306 SH   SOLE 180,306 0 0
SCYNEXIS INC COM NEW 811292200 474 121,242 SH   SOLE 121,242 0 0
SPDR SP BIOTECH ETF ETF 78464A870 24,223 269,500 SH   SOLE 269,500 0 0
STEREOTAXIS INC COM NEW 85916J409 51,028 13,680,554 SH   SOLE 13,680,554 0 0
SURFACE ONCOLOGY INC COM 86877M209 1,999 680,000 SH   SOLE 680,000 0 0
SURGALIGN HOLDINGS INC COM 86882C105 176 579,710 SH   SOLE 579,710 0 0
SUTRO BIOPHARMA INC COM 869367102 696 84,700 SH   SOLE 84,700 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 6,465 371,987 SH   SOLE 371,987 0 0
THESEUS PHARMACEUTICALS INC COM 88369M101 924 80,124 SH   SOLE 80,124 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 1,596 59,452 SH   SOLE 59,452 0 0
VENUS CONCEPT INC COM 92332W105 1,385 968,187 SH   SOLE 968,187 0 0
VIGIL NEUROSCIENCE INC COM 92673K108 701 99,754 SH   SOLE 99,754 0 0
VIKING THERAPEUTICS INC COM 92686J106 1,342 447,400 SH   SOLE 447,400 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 780 390,161 SH   SOLE 390,161 0 0
XENON PHARMACEUTICALS INC COM 98420N105 11,622 380,163 SH   SOLE 380,163 0 0