The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 2,498 105,478 SH   SOLE 105,478 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 2,141 83,000 SH   SOLE 83,000 0 0
ACCURAY INC COM 004397105 4,662 941,800 SH   SOLE 941,800 0 0
ADICET BIO INC COM 007002108 5,037 385,077 SH   SOLE 385,077 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 4,929 275,840 SH   SOLE 275,840 0 0
AERIE PHARMACEUTICALS INC NOTE 1.500%10/0 00771VAB4 1,556 1,500,000 PRN   SOLE 1,500,000 0 0
AFFIMED N V COM N01045108 7,830 989,857 SH   SOLE 989,857 0 0
ALECTOR INC COM 014442107 2,568 127,500 SH   SOLE 127,500 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 1,201 113,302 SH   SOLE 113,302 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 1,928 44,926 SH   SOLE 44,926 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 2,181 430,111 SH   SOLE 430,111 0 0
ARCUS BIOSCIENCES INC COM 03969F109 1,617 57,600 SH   SOLE 57,600 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 5,323 76,715 SH   SOLE 76,715 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 2,995 23,237 SH   SOLE 23,237 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 2,270 677,500 SH   SOLE 677,500 0 0
ATHIRA PHARMA INC COM 04746L104 1,684 91,531 SH   SOLE 91,531 0 0
ATRICURE INC COM 04963C209 8,421 128,529 SH   SOLE 128,529 0 0
BIOHAVEN PHARMACEUTICALS HOLD COM G11196105 6,398 93,600 SH   SOLE 93,600 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 20,215 207,911 SH   SOLE 207,911 0 0
BRAINWAY LTD SPONSORED ADS 10501L106 1,806 200,000 SH   SOLE 200,000 0 0
CARA THERAPEUTICS INC COM 140755109 5,676 261,442 SH   SOLE 261,442 0 0
CARDIOVASCULAR SYSTEMS INC COM 141619106 5,739 149,700 SH   SOLE 149,700 0 0
COGENT BIOSCIENCES INC COM 19240Q201 1,963 223,554 SH   SOLE 223,554 0 0
COMPUGEN LTD ORD M25722105 1,624 189,002 SH   SOLE 189,002 0 0
CONFORMIS INC COM 20717E101 1,287 1,300,000 SH   SOLE 1,300,000 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 148 8,000 SH   SOLE 8,000 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 1,533 337,770 SH   SOLE 337,770 0 0
DEXCOM INC COM 252131107 7,597 21,138 SH   SOLE 21,138 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 15,029 587,756 SH   SOLE 587,756 0 0
FATE THERAPEUTICS INC COM 31189P102 25,919 314,360 SH   SOLE 314,360 0 0
FS DEVELOPMENT CORP II COM CL A 30318F100 2,988 300,000 SH   SOLE 300,000 0 0
GALAPAGOS NV SPON ADR 36315X101 5,795 75,175 SH   SOLE 75,175 0 0
GEMINI THERAPEUTICS INC COM 36870G105 2,033 150,000 SH   SOLE 150,000 0 0
GENFIT S A ADS 372279109 871 188,549 SH   SOLE 188,549 0 0
HARPOON THERAPEUTICS INC COM 41358P106 2,650 126,663 SH   SOLE 126,663 0 0
HOOKIPA PHARMA INC COM 43906K100 4,619 343,455 SH   SOLE 343,455 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 7,794 331,661 SH   SOLE 331,661 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 1,483 459,260 SH   SOLE 459,260 0 0
INFLARX NV COM N44821101 2,340 600,000 SH   SOLE 600,000 0 0
INOGEN INC COM 45780L104 788 15,000 SH   SOLE 15,000 0 0
ISHARES TR NASDAQ BIOTECH ETF 464287556 6,083 40,400 SH   SOLE 40,400 0 0
IVERIC BIO INC COM 46583P102 556 89,951 SH   SOLE 89,951 0 0
JOHNSON AND JOHNSON COM 478160104 1,545 9,400 SH   SOLE 9,400 0 0
KADMON HOLDINGS INC COM 48283N106 1,535 394,561 SH   SOLE 394,561 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 1,505 58,600 SH   SOLE 58,600 0 0
KARUNA THERAPEUTICS INC COM 48576A100 5,771 48,000 SH   SOLE 48,000 0 0
KINNATE BIOPHARMA INC COM 49705R105 1,649 52,915 SH   SOLE 52,915 0 0
KURA ONCOLOGY INC COM 50127T109 1,464 51,800 SH   SOLE 51,800 0 0
LARIMAR THERAPEUTICS INC COM 517125100 1,190 81,432 SH   SOLE 81,432 0 0
LINEAGE CELL THERAPEUTICS INC COM 53566P109 177 75,400 SH   SOLE 75,400 0 0
LIQUIDIA TECHNOLOGIES INC COM NEW 53635D202 1,547 575,000 SH   SOLE 575,000 0 0
LUMINEX CORP COM 55027E102 4,916 154,091 SH   SOLE 154,091 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 655 5,600 SH   SOLE 5,600 0 0
MASIMO CORPORATION COM 574795100 689 3,000 SH   SOLE 3,000 0 0
MEI PHARMA INC COM NEW 55279B202 2,216 646,000 SH   SOLE 646,000 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 4,211 1,249,648 SH   SOLE 1,249,648 0 0
MERSANA THERAPEUTICS INC COM 59045L106 2,011 124,263 SH   SOLE 124,263 0 0
MERUS N V COM N5749R100 3,297 157,841 SH   SOLE 157,841 0 0
MORPHIC HOLDING INC COM 61775R105 11,483 181,467 SH   SOLE 181,467 0 0
NATUS MEDICAL INC COM 639050103 2,450 95,653 SH   SOLE 95,653 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 7,163 73,655 SH   SOLE 73,655 0 0
NEURONETICS INC COM 64131A105 3,138 253,717 SH   SOLE 253,717 0 0
NEXTCURE INC COM 65343E108 651 65,000 SH   SOLE 65,000 0 0
NGM BIOPHARMACEUTICALS INC COM 62921N105 291 10,000 SH   SOLE 10,000 0 0
NURIX THERAPEUTICS INC COM 67080M103 9,523 306,320 SH   SOLE 306,320 0 0
OTONOMY INC COM 68906L105 993 389,592 SH   SOLE 389,592 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 2,087 603,042 SH   SOLE 603,042 0 0
PROQR THERAPEUTICS N V SHS EURO N71542109 7,271 1,100,000 SH   SOLE 1,100,000 0 0
PROTALIX BIOTHERAPEUTICS INC COM 74365A309 5,374 1,204,825 SH   SOLE 1,204,825 0 0
RADIUS HEALTH INC COM NEW 750469207 302 14,500 SH   SOLE 14,500 0 0
RADIUS HEALTH INC NOTE 3.000% 9/0 750469AA6 3,738 4,000,000 PRN   SOLE 4,000,000 0 0
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 3,337 455,933 SH   SOLE 455,933 0 0
REVOLUTION MEDICINES INC COM 76155X100 6,938 151,231 SH   SOLE 151,231 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 942 275,500 SH   SOLE 275,500 0 0
SAGE THERAPEUTICS INC COM 78667J108 13,571 181,306 SH   SOLE 181,306 0 0
SCPHARMACEUTICALS INC COM 810648105 259 38,891 SH   SOLE 38,891 0 0
SCYNEXIS INC COM NEW 811292200 714 89,874 SH   SOLE 89,874 0 0
SPECTRUM PHARMACEUTICALS INC COM 84763A108 644 197,500 SH   SOLE 197,500 0 0
STEREOTAXIS INC COM NEW 85916J409 91,933 13,680,554 SH   SOLE 13,680,554 0 0
SUTRO BIOPHARMA INC COM 869367102 1,935 85,000 SH   SOLE 85,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 1,286 57,500 SH   SOLE 57,500 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 840 41,165 SH   SOLE 41,165 0 0
TRANSLATE BIO INC COM 89374L104 3,717 225,393 SH   SOLE 225,393 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 994 10,509 SH   SOLE 10,509 0 0
VENUS CONCEPT INC COM 92332W105 2,891 1,230,400 SH   SOLE 1,230,400 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 153 18,337 SH   SOLE 18,337 0 0
VIKING THERAPEUTICS INC COM 92686J106 2,830 447,400 SH   SOLE 447,400 0 0
X4 PHARMACEUTICALS INC COM 98420X103 602 69,912 SH   SOLE 69,912 0 0
XENON PHARMACEUTICALS INC COM 98420N105 7,277 406,535 SH   SOLE 406,535 0 0