The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2SEVENTY BIO INC COMMON STOCK 901384107   2,973,737 630,029 SH   SOLE   630,029 0 0
ACCURAY INC COM 004397105   2,200,244 1,222,358 SH   SOLE   1,222,358 0 0
ACELYRIN INC COM 00445A100   2,972,267 602,894 SH   SOLE   602,894 0 0
ACRIVON THERAPEUTICS INC COMMON STOCK 004890109   786,898 112,414 SH   SOLE   112,414 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   324,147 341,064 SH   SOLE   341,064 0 0
ADC THERAPEUTICS SA SHS H0036K147   642,855 204,081 SH   SOLE   204,081 0 0
ADICET BIO INC COM 007002108   864,000 600,000 SH   SOLE   600,000 0 0
ALECTOR INC COM 014442107   4,254,244 912,928 SH   SOLE   912,928 0 0
ALKERMES PLC SHS G01767105   3,378,393 120,700 SH   SOLE   120,700 0 0
ALLOGENE THERAPEUTICS INC COM 019770106   2,940,330 1,050,118 SH   SOLE   1,050,118 0 0
ALTO NEUROSCIENCE INC COM SHS 02157Q109   306,432 26,786 SH   SOLE   26,786 0 0
APREA THERAPEUTICS INC COM NEW 03836J201   377,229 137,174 SH   SOLE   137,174 0 0
AQUESTIVE THERAPEUTICS INC COM 03843E104   2,936,014 589,561 SH   SOLE   589,561 0 0
ARCUS BIOSCIENCES INC COM 03969F109   3,925,203 256,717 SH   SOLE   256,717 0 0
ARS PHARMACEUTICALS INC COM 82835W108   2,150,263 148,294 SH   SOLE   148,294 0 0
ASCENDIS PHARMA A/S NOTE 2.250% 4/0 04351PAD3   4,680,000 4,000,000 PRN   SOLE   4,000,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   13,373,995 89,572 SH   SOLE   89,572 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   2,798,357 254,165 SH   SOLE   254,165 0 0
ATRICURE INC COM 04963C209   17,992,511 641,673 SH   SOLE   641,673 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   1,766,601 486,667 SH   SOLE   486,667 0 0
AXOGEN INC COM 05463X106   13,121,234 935,894 SH   SOLE   935,894 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108   2,765,386 122,200 SH   SOLE   122,200 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   5,069,200 667,000 SH   SOLE   667,000 0 0
BIOHAVEN LTD COM G1110E107   9,350,886 187,130 SH   SOLE   187,130 0 0
BIOMX INC COM NEW 09090D301   409,159 401,136 SH   SOLE   401,136 0 0
BIONTECH SE SPONSORED ADS 09075V102   1,009,545 8,500 SH   SOLE   8,500 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105   543,750 125,000 SH   SOLE   125,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109   11,263,078 121,763 SH   SOLE   121,763 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106   2,322,437 251,346 SH   SOLE   251,346 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100   1,924,412 120,351 SH   SOLE   120,351 0 0
CENTURY THERAPEUTICS INC COM 15673T100   2,914,237 1,704,232 SH   SOLE   1,704,232 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101   1,532,223 243,210 SH   SOLE   243,210 0 0
COMPASS THERAPEUTICS INC COM 20454B104   215,063 116,882 SH   SOLE   116,882 0 0
COMPUGEN LTD ORD M25722105   809,436 447,202 SH   SOLE   447,202 0 0
CYTOKINETICS INC COM NEW 23282W605   21,019,680 398,100 SH   SOLE   398,100 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   10,452,557 750,363 SH   SOLE   750,363 0 0
DEXCOM INC COM 252131107   4,394,606 65,552 SH   SOLE   65,552 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   6,082,811 227,906 SH   SOLE   227,906 0 0
FOGHORN THERAPEUTICS INC COM 344174107   350,652 37,664 SH   SOLE   37,664 0 0
GALAPAGOS NV SPON ADR 36315X101   3,747,738 130,175 SH   SOLE   130,175 0 0
GOSSAMER BIO INC COM 38341P102   1,399,960 1,419,262 SH   SOLE   1,419,262 0 0
GRAIL INC COM 384747101   671,488 48,800 SH   SOLE   48,800 0 0
IDEAYA BIOSCIENCES INC COM 45166A102   14,934,269 471,410 SH   SOLE   471,410 0 0
IMMATICS NV SHS N44445109   1,654,450 145,000 SH   SOLE   145,000 0 0
IMMUNOVANT INC COM 45258J102   1,482,406 51,996 SH   SOLE   51,996 0 0
INOGEN INC COM 45780L104   2,025,263 208,790 SH   SOLE   208,790 0 0
INSULET CORP COM 45784P101   3,700,725 15,900 SH   SOLE   15,900 0 0
ISHARES NASDAQ BIOTECH INDX ETF 464287556   14,924,000 102,500 SH   SOLE   102,500 0 0
ITEOS THERAPEUTICS INC COM 46565G104   1,649,773 161,584 SH   SOLE   161,584 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103   8,380,191 723,678 SH   SOLE   723,678 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106   159,923 192,678 SH   SOLE   192,678 0 0
KEROS THERAPEUTICS INC COM 492327101   4,282,895 73,754 SH   SOLE   73,754 0 0
KURA ONCOLOGY INC COM 50127T109   7,979,511 408,368 SH   SOLE   408,368 0 0
LARIMAR THERAPEUTICS INC COM 517125100   3,237,495 494,274 SH   SOLE   494,274 0 0
LEXEO THERAPEUTICS INC COM 52886X107   2,265,270 250,583 SH   SOLE   250,583 0 0
LINEAGE CELL THERAPEUTICS IN COM 53566P109   1,222,796 1,350,708 SH   SOLE   1,350,708 0 0
MASIMO CORP COM 574795100   399,990 3,000 SH   SOLE   3,000 0 0
MEDIWOUND LTD SHS NEW M68830112   1,164,491 64,479 SH   SOLE   64,479 0 0
MERUS N V COM N5749R100   20,612,147 412,573 SH   SOLE   412,573 0 0
MINERALYS THERAPEUTICS INC COM 603170101   1,774,115 146,500 SH   SOLE   146,500 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   8,021,040 69,615 SH   SOLE   69,615 0 0
NEUROGENE INC COM 64135M105   326,239 7,775 SH   SOLE   7,775 0 0
NEURONETICS INC COM 64131A105   238,362 313,717 SH   SOLE   313,717 0 0
NEVRO CORP COM 64157F103   212,420 38,000 SH   SOLE   38,000 0 0
NYXOAH S A SHS B6S7WD106   1,032,431 108,108 SH   SOLE   108,108 0 0
PERSPECTIVE THERAPEUTICS INC COM NEW 46489V302   3,074,799 230,322 SH   SOLE   230,322 0 0
POLYPID LTD COM M8001Q126   1,061,230 308,497 SH   SOLE   308,497 0 0
PROQR THERAPEUTICS N V SHS EURO N71542109   1,648,159 905,582 SH   SOLE   905,582 0 0
REGULUS THERAPEUTICS INC COM 75915K309   1,405,464 895,200 SH   SOLE   895,200 0 0
REVOLUTION MEDICINES INC COM 76155X100   23,491,028 517,994 SH   SOLE   517,994 0 0
SAGE THERAPEUTICS INC COM 78667J108   781,204 108,200 SH   SOLE   108,200 0 0
SPDR S&P BIOTECH ETF ETF 78464A870   39,668,694 401,505 SH   SOLE   401,505 0 0
SPERO THERAPEUTICS INC COM 84833T103   167,500 125,000 SH   SOLE   125,000 0 0
STEREOTAXIS INC COM NEW 85916J409   27,908,330 13,680,554 SH   SOLE   13,680,554 0 0
STOKE THERAPEUTICS INC COM 86150R107   2,549,278 207,427 SH   SOLE   207,427 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106   1,492,260 34,000 SH   SOLE   34,000 0 0
SUTRO BIOPHARMA INC COM 869367102   1,140,343 329,579 SH   SOLE   329,579 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   10,139,014 526,702 SH   SOLE   526,702 0 0
TANDEM DIABETES CARE INC COM NEW 875372203   8,660,461 204,208 SH   SOLE   204,208 0 0
TOURMALINE BIO INC COM 89157D105   491,318 19,110 SH   SOLE   19,110 0 0
UROGEN PHARMA LTD COM M96088105   5,828,221 458,915 SH   SOLE   458,915 0 0
VERASTEM INC COM NEW 92337C203   381,823 127,700 SH   SOLE   127,700 0 0
VIKING THERAPEUTICS INC COM 92686J106   7,952,749 125,616 SH   SOLE   125,616 0 0
XENON PHARMACEUTICALS INC COM 98420N105   10,777,104 273,739 SH   SOLE   273,739 0 0