The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2SEVENTY BIO INC COMMON STOCK 901384107   6,441,673 1,204,051 SH   SOLE   1,204,051 0 0
ACCURAY INC COM 004397105   3,019,224 1,222,358 SH   SOLE   1,222,358 0 0
ACELYRIN INC COM 00445A100   1,367,462 202,587 SH   SOLE   202,587 0 0
ACRIVON THERAPEUTICS INC COMMON STOCK 004890109   939,160 131,351 SH   SOLE   131,351 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   538,881 341,064 SH   SOLE   341,064 0 0
ADICET BIO INC COM 007002108   1,410,000 600,000 SH   SOLE   600,000 0 0
ALECTOR INC COM 014442107   5,495,827 912,928 SH   SOLE   912,928 0 0
ALTO NEUROSCIENCE INC COM SHS 02157Q109   153,500 10,000 SH   SOLE   10,000 0 0
APREA THERAPEUTICS INC COM NEW 03836J201   917,694 137,174 SH   SOLE   137,174 0 0
AQUESTIVE THERAPEUTICS INC COM 03843E104   2,130,000 500,000 SH   SOLE   500,000 0 0
ARCUS BIOSCIENCES INC COM 03969F109   4,374,817 231,717 SH   SOLE   231,717 0 0
ARS PHARMACEUTICALS INC COM 82835W108   2,444,563 239,194 SH   SOLE   239,194 0 0
ASCENDIS PHARMA A/S NOTE 2.250% 4/0 04351PAD3   4,610,000 4,000,000 PRN   SOLE   4,000,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   13,978,992 92,472 SH   SOLE   92,472 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   3,142,455 223,265 SH   SOLE   223,265 0 0
ATRICURE INC COM 04963C209   8,244,702 271,029 SH   SOLE   271,029 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   1,382,335 216,667 SH   SOLE   216,667 0 0
AXOGEN INC COM 05463X106   7,552,665 935,894 SH   SOLE   935,894 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108   3,042,780 122,200 SH   SOLE   122,200 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   3,604,260 709,500 SH   SOLE   709,500 0 0
BIOHAVEN LTD COM G1110E107   6,493,344 118,730 SH   SOLE   118,730 0 0
BIONTECH SE SPONSORED ADS 09075V102   1,568,250 17,000 SH   SOLE   17,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109   10,127,538 106,763 SH   SOLE   106,763 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106   1,574,595 297,655 SH   SOLE   297,655 0 0
CENTURY THERAPEUTICS INC COM 15673T100   5,464,961 1,307,407 SH   SOLE   1,307,407 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101   2,023,507 243,210 SH   SOLE   243,210 0 0
COMPASS THERAPEUTICS INC COM 20454B104   231,426 116,882 SH   SOLE   116,882 0 0
COMPUGEN LTD ORD M25722105   1,109,921 430,202 SH   SOLE   430,202 0 0
CYTOKINETICS INC COM NEW 23282W605   27,910,791 398,100 SH   SOLE   398,100 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   11,009,969 666,463 SH   SOLE   666,463 0 0
DEXCOM INC COM 252131107   9,092,062 65,552 SH   SOLE   65,552 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   5,585,033 306,197 SH   SOLE   306,197 0 0
GALAPAGOS NV SPON ADR 36315X101   4,191,635 130,175 SH   SOLE   130,175 0 0
GOSSAMER BIO INC COM 38341P102   1,662,929 1,409,262 SH   SOLE   1,409,262 0 0
IDEAYA BIOSCIENCES INC COM 45166A102   19,585,443 446,341 SH   SOLE   446,341 0 0
IMMATICS NV SHS N44445109   1,523,950 145,000 SH   SOLE   145,000 0 0
IMMUNOVANT INC COM 45258J102   950,431 29,416 SH   SOLE   29,416 0 0
INOGEN INC COM 45780L104   1,684,935 208,790 SH   SOLE   208,790 0 0
INSULET CORP COM 45784P101   2,725,260 15,900 SH   SOLE   15,900 0 0
ISHARES NASDAQ BIOTECH INDX ETF 464287556   14,065,050 102,500 SH   SOLE   102,500 0 0
ITEOS THERAPEUTICS INC COM 46565G104   1,344,358 98,560 SH   SOLE   98,560 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103   9,570,700 806,973 SH   SOLE   806,973 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106   290,944 192,678 SH   SOLE   192,678 0 0
KEROS THERAPEUTICS INC COM 492327101   4,485,315 67,754 SH   SOLE   67,754 0 0
KURA ONCOLOGY INC COM 50127T109   8,802,102 412,663 SH   SOLE   412,663 0 0
LARIMAR THERAPEUTICS INC COM 517125100   4,981,871 656,373 SH   SOLE   656,373 0 0
LINEAGE CELL THERAPEUTICS IN COM 53566P109   2,022,136 1,366,308 SH   SOLE   1,366,308 0 0
MASIMO CORP COM 574795100   440,550 3,000 SH   SOLE   3,000 0 0
MEDIWOUND LTD SHS NEW M68830112   2,689,730 188,753 SH   SOLE   188,753 0 0
MERUS N V COM N5749R100   17,066,145 378,995 SH   SOLE   378,995 0 0
MINERALYS THERAPEUTICS INC COM 603170101   1,161,900 90,000 SH   SOLE   90,000 0 0
MORPHIC HOLDING INC COM 61775R105   8,157,530 231,748 SH   SOLE   231,748 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   9,877,141 71,615 SH   SOLE   71,615 0 0
NEURONETICS INC COM 64131A105   1,493,293 313,717 SH   SOLE   313,717 0 0
NEVRO CORP COM 64157F103   404,320 28,000 SH   SOLE   28,000 0 0
PERSPECTIVE THERAPEUTICS INC COM 46489V104   3,693,336 3,103,644 SH   SOLE   3,103,644 0 0
POLYPID LTD COM M8001Q126   853,052 185,446 SH   SOLE   185,446 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105   2,717,853 54,995 SH   SOLE   54,995 0 0
PROQR THERAPEUTICS N V SHS EURO N71542109   2,073,692 905,582 SH   SOLE   905,582 0 0
REGULUS THERAPEUTICS INC COM 75915K309   3,083,178 1,070,548 SH   SOLE   1,070,548 0 0
REVOLUTION MEDICINES INC COM 76155X100   16,498,344 511,894 SH   SOLE   511,894 0 0
SPDR S&P BIOTECH ETF ETF 78464A870   40,917,991 431,215 SH   SOLE   431,215 0 0
SPERO THERAPEUTICS INC COM 84833T103   215,000 125,000 SH   SOLE   125,000 0 0
STEREOTAXIS INC COM NEW 85916J409   35,706,246 13,680,554 SH   SOLE   13,680,554 0 0
STOKE THERAPEUTICS INC COM 86150R107   1,957,500 145,000 SH   SOLE   145,000 0 0
SUTRO BIOPHARMA INC COM 869367102   1,887,546 334,079 SH   SOLE   334,079 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   15,697,861 659,574 SH   SOLE   659,574 0 0
SYROS PHARMACEUTICALS INC COM NEW 87184Q206   726,798 135,850 SH   SOLE   135,850 0 0
TANDEM DIABETES CARE INC COM NEW 875372203   9,143,145 258,208 SH   SOLE   258,208 0 0
VIGIL NEUROSCIENCE INC COM 92673K108   244,889 71,815 SH   SOLE   71,815 0 0
VIKING THERAPEUTICS INC COM 92686J106   15,917,594 194,117 SH   SOLE   194,117 0 0
XENON PHARMACEUTICALS INC COM 98420N105   11,784,464 273,739 SH   SOLE   273,739 0 0