The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2SEVENTY BIO INC COMMON STOCK 901384107   6,180,676 1,447,465 SH   SOLE   1,447,465 0 0
ACCURAY INC COM 004397105   3,459,273 1,222,358 SH   SOLE   1,222,358 0 0
ACELYRIN INC COM 00445A100   2,769,152 371,200 SH   SOLE   371,200 0 0
ACRIVON THERAPEUTICS INC COMMON STOCK 004890109   646,247 131,351 SH   SOLE   131,351 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   278,394 351,064 SH   SOLE   351,064 0 0
ALECTOR INC COM 014442107   4,867,042 609,905 SH   SOLE   609,905 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   1,803,892 122,547 SH   SOLE   122,547 0 0
ARCUS BIOSCIENCES INC COM 03969F109   4,444,895 232,717 SH   SOLE   232,717 0 0
ARGEN SE SPONSORED ADR 04016X101   1,369,548 3,600 SH   SOLE   3,600 0 0
ARS PHARMACEUTICALS INC COM 82835W108   1,705,206 311,169 SH   SOLE   311,169 0 0
ASCENDIS PHARMA A/S NOTE 2.250% 4/0 04351PAD3   4,138,750 4,000,000 PRN   SOLE   4,000,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   15,551,298 123,472 SH   SOLE   123,472 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   3,448,381 449,008 SH   SOLE   449,008 0 0
ATRICURE INC COM 04963C209   4,480,130 125,529 SH   SOLE   125,529 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   1,230,491 191,070 SH   SOLE   191,070 0 0
AXOGEN INC COM 05463X106   6,392,156 935,894 SH   SOLE   935,894 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108   2,209,376 122,200 SH   SOLE   122,200 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   4,249,905 709,500 SH   SOLE   709,500 0 0
BIOHAVEN LTD COM G1110E107   7,223,442 168,772 SH   SOLE   168,772 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109   10,226,003 110,863 SH   SOLE   110,863 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106   1,998,892 308,471 SH   SOLE   308,471 0 0
CENTURY THERAPEUTICS INC COM 15673T100   4,340,591 1,307,407 SH   SOLE   1,307,407 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101   1,688,750 193,000 SH   SOLE   193,000 0 0
COMPASS THERAPEUTICS INC COM 20454B104   182,336 116,882 SH   SOLE   116,882 0 0
COMPUGEN LTD ORD M25722105   406,300 205,202 SH   SOLE   205,202 0 0
CULLINAN ONCOLOGY INC COM 230031106   1,297,024 127,284 SH   SOLE   127,284 0 0
CYTOKINETICS INC COM NEW 23282W605   33,396,000 400,000 SH   SOLE   400,000 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   10,022,360 686,463 SH   SOLE   686,463 0 0
DEXCOM INC COM 252131107   8,382,528 67,552 SH   SOLE   67,552 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   4,916,261 449,384 SH   SOLE   449,384 0 0
ELEVATION ONCOLOGY INC COM 28623U101   241,650 450,000 SH   SOLE   450,000 0 0
GALAPAGOS NV SPON ADR 36315X101   5,291,614 130,175 SH   SOLE   130,175 0 0
GOSSAMER BIO INC COM 38341P102   1,346,897 1,476,052 SH   SOLE   1,476,052 0 0
IDEAYA BIOSCIENCES INC COM 45166A102   18,371,413 516,341 SH   SOLE   516,341 0 0
IMMATICS NV SHS N44445109   1,105,650 105,000 SH   SOLE   105,000 0 0
IMMUNOGEN INC COM 45253H101   5,742,049 193,661 SH   SOLE   193,661 0 0
IMMUNOVANT INC COM 45258J102   1,716,460 40,742 SH   SOLE   40,742 0 0
INOGEN INC COM 45780L104   82,350 15,000 SH   SOLE   15,000 0 0
ISHARES NASDAQ BIOTECH INDX ETF 464287556   13,924,625 102,500 SH   SOLE   102,500 0 0
ITEOS THERAPEUTICS INC COM 46565G104   1,079,232 98,560 SH   SOLE   98,560 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103   7,362,642 601,032 SH   SOLE   601,032 0 0
KARUNA THERAPEUTICS INC COM 48576A100   15,238,374 48,145 SH   SOLE   48,145 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106   166,666 192,678 SH   SOLE   192,678 0 0
KEROS THERAPEUTICS INC COM 492327101   2,956,593 74,361 SH   SOLE   74,361 0 0
KINNATE BIOPHARMA INC COM 49705R105   118,500 50,000 SH   SOLE   50,000 0 0
KURA ONCOLOGY INC COM 50127T109   7,084,796 492,684 SH   SOLE   492,684 0 0
LARIMAR THERAPEUTICS INC COM 517125100   1,473,622 323,873 SH   SOLE   323,873 0 0
MACROGENICS INC COM 556099109   1,464,645 152,250 SH   SOLE   152,250 0 0
MASIMO CORP COM 574795100   351,630 3,000 SH   SOLE   3,000 0 0
MEDIWOUND LTD SHS NEW M68830112   2,620,331 257,653 SH   SOLE   257,653 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107   1,799,058 778,813 SH   SOLE   778,813 0 0
MERUS N V COM N5749R100   12,508,925 454,870 SH   SOLE   454,870 0 0
MINERALYS THERAPEUTICS INC COM 603170101   130,720 15,200 SH   SOLE   15,200 0 0
MIRATI THERAPEUTICS INC COM 60468T105   5,251,486 89,387 SH   SOLE   89,387 0 0
MORPHIC HOLDING INC COM 61775R105   6,692,882 231,748 SH   SOLE   231,748 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   9,567,752 72,615 SH   SOLE   72,615 0 0
NEURONETICS INC COM 64131A105   909,779 313,717 SH   SOLE   313,717 0 0
NEVRO CORP COM 64157F103   602,560 28,000 SH   SOLE   28,000 0 0
ORIC PHARMACEUTICALS INC COM 68622P109   669,732 72,797 SH   SOLE   72,797 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105   2,652,903 63,300 SH   SOLE   63,300 0 0
PROQR THERAPEUTICS N V SHS EURO N71542109   1,862,352 940,582 SH   SOLE   940,582 0 0
REGULUS THERAPEUTICS INC COM 75915K309   1,422,143 1,111,049 SH   SOLE   1,111,049 0 0
REVOLUTION MEDICINES INC COM 76155X100   14,681,120 511,894 SH   SOLE   511,894 0 0
SAGE THERAPEUTICS INC COM 78667J108   5,309,150 245,000 SH   SOLE   245,000 0 0
SPDR S&P BIOTECH ETF ETF 78464A870   43,216,360 484,000 SH   SOLE   484,000 0 0
SPERO THERAPEUTICS INC COM 84833T103   183,750 125,000 SH   SOLE   125,000 0 0
SPRUCE BIOSCIENCES INC COM 85209E109   1,607,134 548,510 SH   SOLE   548,510 0 0
STEREOTAXIS INC COM NEW 85916J409   23,940,970 13,680,554 SH   SOLE   13,680,554 0 0
SUTRO BIOPHARMA INC COM 869367102   1,214,409 283,079 SH   SOLE   283,079 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   16,047,024 742,574 SH   SOLE   742,574 0 0
SYROS PHARMACEUTICALS INC COM NEW 87184Q206   1,673,954 214,885 SH   SOLE   214,885 0 0
TANDEM DIABETES CARE INC COM NEW 875372203   6,528,543 220,708 SH   SOLE   220,708 0 0
VIGIL NEUROSCIENCE INC COM 92673K108   242,735 71,815 SH   SOLE   71,815 0 0
VIKING THERAPEUTICS INC COM 92686J106   4,619,318 248,217 SH   SOLE   248,217 0 0
VISTAGEN THERAPEUTICS INC COM 92840H400   215,294 41,886 SH   SOLE   41,886 0 0
XENON PHARMACEUTICALS INC COM 98420N105   12,746,598 276,739 SH   SOLE   276,739 0 0