The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2SEVENTY BIO INC COMMON STOCK 901384107   5,674,063 1,447,465 SH   SOLE   1,447,465 0 0
ACCURAY INC COM 004397105   3,324,814 1,222,358 SH   SOLE   1,222,358 0 0
ACELYRIN INC COM 00445A100   74,241 7,300 SH   SOLE   7,300 0 0
ACRIVON THERAPEUTICS INC COMMON STOCK 004890109   734,705 76,852 SH   SOLE   76,852 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   273,830 351,064 SH   SOLE   351,064 0 0
ADICET BIO INC COM 007002108   1,091,964 797,054 SH   SOLE   797,054 0 0
ALECTOR INC COM 014442107   4,075,518 628,938 SH   SOLE   628,938 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   2,243,836 122,547 SH   SOLE   122,547 0 0
ARCUS BIOSCIENCES INC COM 03969F109   3,997,770 222,717 SH   SOLE   222,717 0 0
ASCENDIS PHARMA A/S NOTE 2.250% 4/0 04351PAD3   3,691,250 4,000,000 PRN   SOLE   4,000,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   12,754,892 136,212 SH   SOLE   136,212 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   2,204,378 295,493 SH   SOLE   295,493 0 0
ATRICURE INC COM 04963C209   5,498,170 125,529 SH   SOLE   125,529 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   2,162,829 928,253 SH   SOLE   928,253 0 0
AXOGEN INC COM 05463X106   4,679,470 935,894 SH   SOLE   935,894 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108   2,454,998 122,200 SH   SOLE   122,200 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   4,616,160 652,000 SH   SOLE   652,000 0 0
BIOHAVEN LTD COM G1110E107   910,350 35,000 SH   SOLE   35,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109   12,530,945 249,521 SH   SOLE   249,521 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106   1,746,011 432,181 SH   SOLE   432,181 0 0
CENTURY THERAPEUTICS INC COM 15673T100   2,614,814 1,307,407 SH   SOLE   1,307,407 0 0
CEREVEL THERAPEUTICS HOLDINGS INC COM 15678U128   1,357,826 62,200 SH   SOLE   62,200 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101   1,428,200 193,000 SH   SOLE   193,000 0 0
COMPASS THERAPEUTICS INC COM 20454B104   230,258 116,882 SH   SOLE   116,882 0 0
COMPUGEN LTD ORD M25722105   190,838 205,202 SH   SOLE   205,202 0 0
CULLINAN ONCOLOGY INC COM 230031106   1,151,920 127,284 SH   SOLE   127,284 0 0
CYTOKINETICS INC COM NEW 23282W605   14,127,189 479,538 SH   SOLE   479,538 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   7,195,901 586,463 SH   SOLE   586,463 0 0
DEXCOM INC COM 252131107   6,302,602 67,552 SH   SOLE   67,552 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   2,976,070 519,384 SH   SOLE   519,384 0 0
ELEVATION ONCOLOGY INC COM 28623U101   298,170 450,000 SH   SOLE   450,000 0 0
GALAPAGOS NV SPON ADR 36315X101   2,079,046 60,175 SH   SOLE   60,175 0 0
GOSSAMER BIO INC COM 38341P102   1,229,256 1,476,052 SH   SOLE   1,476,052 0 0
IDEAYA BIOSCIENCES INC COM 45166A102   13,485,144 499,820 SH   SOLE   499,820 0 0
IMMUNOGEN INC COM 45253H101   1,317,210 83,000 SH   SOLE   83,000 0 0
IMMUNOVANT INC COM 45258J102   863,775 22,500 SH   SOLE   22,500 0 0
INOGEN INC COM 45780L104   78,300 15,000 SH   SOLE   15,000 0 0
ISHARES NASDAQ BIOTECH INDX ETF 464287556   12,534,725 102,500 SH   SOLE   102,500 0 0
ITEOS THERAPEUTICS INC COM 46565G104   1,079,232 98,560 SH   SOLE   98,560 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103   5,831,273 605,532 SH   SOLE   605,532 0 0
KARUNA THERAPEUTICS INC COM 48576A100   8,940,296 52,873 SH   SOLE   52,873 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106   258,189 192,678 SH   SOLE   192,678 0 0
KEROS THERAPEUTICS INC COM 492327101   2,102,837 65,961 SH   SOLE   65,961 0 0
KINNATE BIOPHARMA INC COM 49705R105   147,251 105,179 SH   SOLE   105,179 0 0
KURA ONCOLOGY INC COM 50127T109   5,023,150 550,784 SH   SOLE   550,784 0 0
LARIMAR THERAPEUTICS INC COM 517125100   1,293,123 327,373 SH   SOLE   327,373 0 0
MACROGENICS INC COM 556099109   1,204,591 258,496 SH   SOLE   258,496 0 0
MASIMO CORP COM 574795100   263,040 3,000 SH   SOLE   3,000 0 0
MEDIWOUND LTD SHS NEW M68830112   2,741,428 257,653 SH   SOLE   257,653 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107   1,241,642 962,513 SH   SOLE   962,513 0 0
MERSANA THERAPEUTICS INC COM 59045L106   932,228 734,038 SH   SOLE   734,038 0 0
MERUS N V COM N5749R100   11,433,235 484,870 SH   SOLE   484,870 0 0
MIRATI THERAPEUTICS INC COM 60468T105   4,046,158 92,887 SH   SOLE   92,887 0 0
MORPHIC HOLDING INC COM 61775R105   5,309,347 231,748 SH   SOLE   231,748 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   8,281,688 73,615 SH   SOLE   73,615 0 0
NEURONETICS INC COM 64131A105   423,518 313,717 SH   SOLE   313,717 0 0
NEVRO CORP COM 64157F103   538,160 28,000 SH   SOLE   28,000 0 0
NEXTCURE INC COM 65343E108   214,379 166,185 SH   SOLE   166,185 0 0
NURIX THERAPEUTICS INC COM 67080M103   4,375,623 556,695 SH   SOLE   556,695 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105   2,208,113 67,300 SH   SOLE   67,300 0 0
PROQR THERAPEUTICS N V SHS EURO N71542109   1,222,757 940,582 SH   SOLE   940,582 0 0
REGULUS THERAPEUTICS INC COM 75915K309   1,522,137 1,111,049 SH   SOLE   1,111,049 0 0
REVOLUTION MEDICINES INC COM 76155X100   13,103,546 473,394 SH   SOLE   473,394 0 0
SPDR S&P BIOTECH ETF ETF 78464A870   41,256,300 565,000 SH   SOLE   565,000 0 0
SPERO THERAPEUTICS INC COM 84833T103   151,250 125,000 SH   SOLE   125,000 0 0
SPRUCE BIOSCIENCES INC COM 85209E109   1,288,494 570,130 SH   SOLE   570,130 0 0
STEREOTAXIS INC COM NEW 85916J409   21,615,275 13,680,554 SH   SOLE   13,680,554 0 0
SUTRO BIOPHARMA INC COM 869367102   982,284 283,079 SH   SOLE   283,079 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   6,655,576 458,373 SH   SOLE   458,373 0 0
SYROS PHARMACEUTICALS INC COM NEW 87184Q206   1,050,218 265,878 SH   SOLE   265,878 0 0
TANDEM DIABETES CARE INC COM NEW 875372203   4,584,105 220,708 SH   SOLE   220,708 0 0
THIRD HARMONIC BIO INC COM 88427A107   1,917,000 300,000 SH   SOLE   300,000 0 0
VIGIL NEUROSCIENCE INC COM 92673K108   928,740 172,308 SH   SOLE   172,308 0 0
VIKING THERAPEUTICS INC COM 92686J106   3,538,581 319,655 SH   SOLE   319,655 0 0
XENON PHARMACEUTICALS INC COM 98420N105   9,583,178 280,538 SH   SOLE   280,538 0 0