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Note 14 - License, Collaboration and Distribution Agreements (Tables)
12 Months Ended
Dec. 31, 2019
Notes Tables  
Contract with Customer, Asset and Liability [Table Text Block]
   
Balance at
Beginning of the
Period
   
Additions
   
Deductions
   
Balance at the end
of the Period
 
   
(in thousands)
 
Contract liabilities: deferred revenue
  $
41
    $
-
    $
(41
)   $
-
 
Contract liabilities: accrued liabilities
   
1,432
     
5,708
     
(6,706
)    
434
 
Total
  $
1,473
    $
5,708
    $
(6,747
)   $
434
 
Disaggregation of Revenue [Table Text Block]
   
Year Ended December 31,
 
   
2019
   
2018
 
Revenue recognized in the period from:
               
Amounts included in contract liabilities at the beginning of the year:
               
Performance obligations satisfied
  $
1,473
    $
1,453
 
New activities during the year:
               
Performance obligations satisfied
   
5,126
     
11,055
 
                 
    $
6,599
    $
12,508
 
Schedule of Revenue Recognized [Table Text Block]
   
Year Ended
 
   
December 31,
 
(in thousands)
 
2019
   
2018
   
2017
 
Amortization of upfront technology and access fees
  $
41
    $
34
    $
103
 
Product revenue
   
209
     
169
     
1,956
 
Total revenue recognized
  $
250
    $
203
    $
2,059