The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABCELLERA BIOLOGICS INC COM 00288U106   11,415,649 1,126,915 SH   SOLE   1,126,915 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102   44,117,850 500,827 SH   SOLE   500,827 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   26,616,800 112,000 SH   SOLE   100,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109   25,590,939 2,095,900 SH   SOLE   2,100,000 0 0
ARCELLX, INC. COMMON STOCK 03940C100   45,974,940 1,484,020 SH   SOLE   3,191,878 0 0
APPLE INC COM 037833100   47,957,683 369,104 SH   SOLE   461,379 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210   123,907,128 226,770 SH   SOLE   226,770 0 0
BELLUS HEALTH INC. COM NEW 07987C204   13,958,250 1,698,084 SH   SOLE   1,698,084 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   32,878,773 317,700 SH   SOLE   317,500 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109   16,209,700 370,000 SH   SOLE   316,674 0 0
BOSTON SCIENTIFIC CORP COM 101137107   62,607,058 1,353,081 SH   SOLE   1,762,942 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104   71,928,156 2,508,830 SH   SOLE   2,508,830 0 0
CABLE ONE INC COM 12685J105   66,988,162 94,103 SH   SOLE   80,023 0 0
CATALENT INC COM 148806102   73,495,839 1,632,878 SH   SOLE   1,632,878 0 0
CORCEPT THERAPEUTICS INC COM 218352102   68,602,468 3,377,768 SH   SOLE   3,327,768 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   13,488,143 737,057 SH   SOLE   631,627 0 0
CYTEIR THERAPEUTICS INC COM 23284P103   6,501,681 3,940,413 SH   SOLE   3,940,413 0 0
DICE THERAPEUTICS, INC. COM 23345J104   14,508,000 465,000 SH   SOLE   465,000 0 0
DISC MEDICINE, INC. COM 254604101   46,557,962 2,340,772 SH   SOLE   2,340,772 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   54,281,025 6,071,703 SH   SOLE   6,071,703 0 0
GALECTO INC COM 36322Q107   2,872,460 2,497,791 SH   SOLE   2,497,791 0 0
GALERA THERAPEUTICS INC COM 36338D108   3,663,941 2,459,021 SH   SOLE   2,459,021 0 0
INARI MED INC COM 45332Y109   15,305,248 240,800 SH   SOLE   213,200 0 0
INSMED INC COM PAR $.01 457669307   16,783,200 840,000 SH   SOLE   770,000 0 0
INSPIRE MED SYS INC COM 457730109   15,945,012 63,304 SH   SOLE   60,900 0 0
IO BIOTECH INC COM 449778109   7,539,244 3,277,932 SH   SOLE   3,277,932 0 0
KEZAR LIFE SCIENCES INC COM 49372L100   8,272,000 1,175,000 SH   SOLE   598,377 0 0
KINNATE BIOPHARMA INC COM 49705R105   4,975,813 815,707 SH   SOLE   815,707 0 0
LAVA THERAPEUTICS NV SHS N51517105   11,645,592 3,327,312 SH   SOLE   3,327,312 0 0
MARQETA INC CLASS A COM 57142B104   2,697,919 441,558 SH   SOLE   441,558 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   32,841,764 1,684,193 SH   SOLE   1,684,193 0 0
PHARVARIS N V COM N69605108   13,357,204 1,187,307 SH   SOLE   610,000 0 0
PULMONX CORP COM 745848101   4,303,979 510,555 SH   SOLE   510,555 0 0
RALLYBIO CORP COM 75120L100   15,084,766 2,296,007 SH   SOLE   630,921 0 0
RENEO PHARMACEUTICALS INC COM 75974E103   7,992,778 3,430,377 SH   SOLE   3,430,377 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   16,634,500 850,000 SH   SOLE   632,822 0 0
SALESFORCE.COM, INC. COM 79466L302   76,703,315 578,500 SH   SOLE   578,500 0 0
SEAGEN INC. COM 81181C104   26,987,100 210,000 SH   SOLE   75,000 0 0
SILK RD MED INC COM 82710M100   14,560,756 275,511 SH   SOLE   275,511 0 0
STERIS PLC SHS USD G8473T100   86,377,112 467,687 SH   SOLE   467,687 0 0
STRYKER CORPORATION COM 863667101   194,844,105 796,941 SH   SOLE   796,941 0 0
SPERO THERAPEUTICS INC COM 84833T103   811,200 468,902 SH   SOLE   468,902 0 0
SPRUCE BIOSCIENCES INC COM 85209E109   4,952,227 4,514,336 SH   SOLE   4,514,336 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100   52,946,002 710,780 SH   SOLE   710,780 0 0
TREACE MED CONCEPTS INC COM 89455T109   14,651,918 637,317 SH   SOLE   588,308 0 0
VAXCYTE INC COM 92243G108   34,763,750 725,000 SH   SOLE   823,705 0 0
VECTIVBIO HLDG AG ORD SHS H9060V101   28,919,931 3,339,484 SH   SOLE   3,339,484 0 0
VERVE THERAPEUTICS INC COM 92539P101   17,629,998 911,111 SH   SOLE   911,111 0 0