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Note 11 - Stock-based Compensation (Tables)
3 Months Ended
Mar. 31, 2018
Notes Tables  
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
   
Three Months Ended
 
   
March 31,
 
   
2018
   
2017
 
Expected terms (years)
 
 6.0
-
6.5
   
 5.95
-
9.93
 
Volatility
 
 32.1
-
33.7%
   
 33.8
-
40.6%
 
Risk-free rate
 
 2.6
-
2.7%
   
 2.1
-
2.4%
 
Dividend yield
 
 
—%
 
   
 
—%
 
 
Share-based Compensation, Stock Options, Activity [Table Text Block]
   
 
 
 
 
 
 
 
 
Weighted
   
Weighted
 
   
 
 
 
 
 
 
 
 
Average
   
Average
 
   
Options
   
Number of
   
Exercise
   
Remaining
 
   
Available
   
Options
   
Price
   
Contractual
 
   
for Grant
   
Outstanding
   
per Share
   
Life in Years
 
Balance
— December 31, 2017
   
1,601,202
     
6,521,146
    $
1.19
     
6.9
 
Additional shares reserved
   
1,918,868
     
—
     
 
     
 
 
Options granted
   
(1,802,704
)    
1,802,704
    $
1.32
     
 
 
Options forfeited/cancelled/repurchase
   
171,057
     
(171,057
)   $
2.35
     
 
 
Balance
—
March 31, 2018
   
1,888,423
     
8,152,793
    $
1.20
     
7.3
 
Vested or expected to vest at March 31, 2018
   
 
     
7,734,708
    $
1.17
     
7.2
 
Exercisable at March 31, 2018
   
 
     
4,490,966
    $
0.81
     
5.6
 
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
   
Three Months Ended
 
   
March 31,
 
   
2018
   
2017
 
Cost of goods sold
  $
27
    $
19
 
Research and development
   
26
     
11
 
Selling, general and administrative
   
157
     
93
 
Total
  $
210
    $
123