<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>5</documentType>

    <periodOfReport>2007-12-31</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <form3HoldingsReported>0</form3HoldingsReported>

    <form4TransactionsReported>0</form4TransactionsReported>

    <issuer>
        <issuerCik>0001357459</issuerCik>
        <issuerName>Neuralstem, Inc.</issuerName>
        <issuerTradingSymbol>CUR</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001386042</rptOwnerCik>
            <rptOwnerName>JOHE KARL</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>9700 GREAT SENECA HIGHWAY</rptOwnerStreet1>
            <rptOwnerStreet2>STE 240</rptOwnerStreet2>
            <rptOwnerCity>ROCKVILLE</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>20850</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Scientific Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
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            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2007-08-17</value>
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                <equitySwapInvolved>0</equitySwapInvolved>
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                </transactionShares>
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            </postTransactionAmounts>
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        <nonDerivativeTransaction>
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        <nonDerivativeTransaction>
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    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">N/A</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Karl Johe</signatureName>
        <signatureDate>2008-02-15</signatureDate>
    </ownerSignature>
</ownershipDocument>
