Condensed Consolidated Statements of Operations (Unaudited) (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		6 Months Ended
	Jun. 30, 2012	Jun. 30, 2011	Jun. 30, 2012	Jun. 30, 2011
Condensed Consolidated Statements of Operations [Abstract]
Net product revenue	$ 844	$ 486	$ 1,675	$ 1,062
Collaborative revenue	2,213	1,997	4,355	4,592
Total revenues	3,057	2,483	6,030	5,654
Operating expenses:
Cost of goods sold	94	147	775	255
Research and development	1,539	4,243	4,472	8,200
Selling, general and administrative	3,424	10,350	10,687	20,632
Total operating expenses	5,057	14,740	15,934	29,087
Loss from operations	(2,000)	(12,257)	(9,904)	(23,433)
Interest income	11	20	23	46
Interest expense	(3,468)	(2,300)	(6,688)	(4,500)
Other (expense) income, net	(16)	(30)	(76)	(42)
Net loss	$ (5,473)	$ (14,567)	$ (16,645)	$ (27,929)
Basic and diluted net loss per share	$ (0.17)	$ (0.81)	$ (0.51)	$ (1.56)
Shares used to compute basic and diluted net loss per share	33,078	17,903	32,429	17,887