Document and Entity Information {Abstract} Document And Entity Information [Abstract] Statement [Table] Statement [Line Items] Document Type Amendment Flag Document Period End Date Document Fiscal Period Focus Document Fiscal Year Focus Entity Registrant Name Entity Central Index Key Current Fiscal Year End Date Entity Filer Category Entity Common Stock, Shares Outstanding Entity Well-known Seasoned Issuer Entity Public Float Entity Current Reporting Status Entity Voluntary Filers Consolidated Balance Sheets [Abstract] Assets Abstract Assets Cash and cash equivalents Cash and cash equivalents, beginning of period Cash and Cash Equivalents, at Carrying Value, Beginning Balance Cash and cash equivalents, end of period Cash and cash equivalents, beginning of period Cash and Cash Equivalents, at Carrying Value, Total Available-for-sale Securities, Current Short-term investments Available-for-sale Securities, Current, Total Short-term investments Trade receivable Trade receivable Accounts Receivable, Net, Current, Total Amount due from collaboration partner, within one year of the balance sheet date (or the normal operating cycle, whichever is longer), for goods or services that have been delivered or sold under the terms of an collaboration agreement. Receivable From Collaboration Partner Receivable from collaboration partner Inventory Net Inventory, Net, Total Inventories Total inventories Total inventories Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current, Total Restricted Cash And Cash Equivalents At Carrying Value Restricted cash Total current assets Total current assets Property and equipment, net Property, Plant and Equipment, Net, Ending Balance Property, Plant and Equipment, Net, Beginning Balance Property, Plant and Equipment, Net, Total Restricted cash Restricted cash Other assets Other Assets, Noncurrent, Total Total Assets Total Assets Total assets Liabilities and Stockholders' Deficit Accounts payable Accounts Payable, Current, Total Accrued compensation Employee-related Liabilities, Current, Total Carrying value as of the balance sheet date of obligations incurred and payable, pertaining to research and development costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Accrued research and development Accrued research and development Accrued Research and Development Other accrued expenses Accrued Liabilities, Current, Total Deferred product revenue, net Deferred Revenue, Current, Total Net deferred product revenues The carrying amount of consideration received or receivable from a collaboration partner as of the balance sheet date on potential earnings that were not recognized as revenue in conformity with GAAP, and which are expected to be recognized as such within one year or the normal operating cycle. Deferred collaborative revenue current Deferred collaboration revenue Long Term Debt And Capital Lease Obligations Current Long-term obligations-current portion Long-term Debt and Capital Lease Obligations, Current, Total Less: Long term obligations - current portion Total current liabilities Total current liabilities Non-current liabilities Non-current liabilities: The carrying amount of consideration received or receivable from a collaboration partner as of the balance sheet date on potential earnings that were not recognized as revenue in conformity with GAAP, and which are not expected to be recognized as such within one year or the normal operating cycle, if longer, including sales, license fees, and royalties, but excluding interest income. Deferred collaborative revenue Non current Deferred collaboration revenue Other Liabilities, Noncurrent Other long-term liabilities Other Liabilities, Noncurrent, Total Other Long-term Debt, Noncurrent Long-term obligations Total non-current liabilities Total non-current liabilities Commitments and Contingencies'' Commitments and contingencies Common Stock Value Stockholders' deficit: Common Stock Common stock, $0.001 par value; 100,000,000 shares authorized at December 31, 2011 and 2010; 17,869,108 and 17,869,108 shares issued and outstanding at December 31, 2011, and 2010, respectively Common Stock, Value, Issued, Ending Balance Common Stock, Value, Issued, Beginning Balance Stockholders' equity (deficit): Common Stock, Value, Issued, Total Common stock, $0.001 par value; 100,000,000 shares authorized at December 31, 2011 and 2010; 29,897,186 and 17,869,108 shares issued and outstanding at December 31, 2011 and 2010, respectively Additional Paid in Capital, Common Stock Additional Paid in Capital, Common Stock, Ending Balance Additional Paid in Capital, Common Stock, Beginning Balance Additional paid-in capital Accumulated other comprehensive income (loss) Accumulated Other Comprehensive Income (Loss), Net of Tax, Ending Balance Accumulated Other Comprehensive Income (Loss), Net of Tax, Beginning Balance Accumulated other comprehensive income (loss) Accumulated Other Comprehensive Income (Loss), Net of Tax, Total Accumulated deficit Retained Earnings (Accumulated Deficit), Ending Balance Retained Earnings (Accumulated Deficit), Beginning Balance Retained Earnings (Accumulated Deficit), Total Total stockholders' equity (deficit) Total stockholders' deficit Balance Balance Total stockholders' equity (deficit) Total stockholders' deficit Total liabilities and stockholders' equity (deficit) Total liabilities and stockholders' deficit Common Stock, Par or Stated Value Per Share Common stock, par or stated value per share Common Stock, Shares Authorized Common stock, shares authorized Common Stock, Shares, Issued Common Stock, Shares, Issued, Total Common stock, shares, issued Common Stock, Shares, Outstanding Common Stock, Shares, Outstanding, Ending Balance Common Stock, Shares, Outstanding, Beginning Balance Common stock, shares, outstanding Consolidated Statements Of Operations [Abstract] Net product revenue Sales Revenue, Net, Total Recognition of net revenue Total revenue from sale of goods and services rendered during the reporting period under a collaboration agreement. Collaborative Revenue Collaboration revenue Collaborative revenue Revenues Total revenues Operating expenses: Cost of goods sold Cost of Goods Sold, Total Research and development Research and development expenses Research and Development Expense, Total Selling, general and administrative Selling, general and administrative expenses Selling, General and Administrative Expense, Total Operating Expenses Total Total operating expenses Loss from operations Loss from operations Interest income Interest expense Interest expense Interest Expense, Total Other expenses, net Other income (expense), net Other Nonoperating Income (Expense), Total Net loss Net loss Net loss Earnings Per Share, Basic and Diluted Earnings Per Share, Basic and Diluted, Total Basic and diluted net loss per share Basic and diluted net loss per share Basic and diluted net loss per share The average number of shares or units issued and outstanding that are used in calculating basic and diluted EPS. Weighted Average Number Of Outstanding Shares Basic And Diluted Shares used to compute basic and diluted net loss per share Weighted-average common shares outstanding Consolidated Statement Of Stockholders' (Deficit) Equity [Abstract] Statement, Equity Components [Axis] Equity Component [Domain] Equity Component [Domain] Parent [Member] Parent [Member] Common Stock [Member] Common Stock [Member] Additional Paid In Capital [Member] Additional Paid-In Capital [Member] Deferred Compensation Share Based Payments [Member] Deferred Stock-Based Compensation [Member] Accumulated Other Comprehensive Income [Member] Accumulated Other Comprehensive Income (Loss) [Member] Retained Earnings [Member] Accumulated Deficit [Member] Shares, Outstanding Balance, shares Balance, shares Stock Issued During Period, Value, Stock Options Exercised Issuance of common stock upon exercise of stock options for cash Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Issuance of common stock upon exercise of stock options for cash, shares Issuance of common stock upon vesting of early exercised stock options. Issuance of Common Stock upon Vesting of Early Exercised Stock Options Issuance of common stock at $3.00 - $3.75 per share upon vesting of early exercised stock options Issuance of common stock upon vesting of early exercised stock options, shares. Issuance of Common Stock upon Vesting of Early Exercised Stock Options Shares Issuance of common stock at $3.00 - $3.75 per share upon vesting of early exercised stock options, shares Stock Issued During Period, Value, Employee Stock Purchase Plan Issuance of common stock under the Employee Stock Purchase Plan Stock Issued During Period, Shares, Employee Stock Purchase Plans Issuance of common stock under the Employee Stock Purchase Plan, shares Stock Issued During Period, Value, Share-based Compensation, Net of Forfeitures Stock Issued During Period, Value, Share-based Compensation, Net of Forfeitures, Total Stock-based compensation Stock Issued During Period, Value, New Issues Issuance of common stock, net of offering costs Stock Issued During Period, Shares, New Issues Issuance of common stock, net of offering costs, shares Issuance of warrant to purchase stock to investors including fair value. Issuance of Warrant to Purchase Stock to Investors Including Fair Value Issuance of warrant to purchase stock to investors at $0.14 per share including fair value Issuance of warrant to purchase stock to investor at fair value. Issuance of Warrant to Purchase Stock to Investor at Fair Value Issuance of warrant to purchase stock to investor at fair value Amortization of deferred stock-based compensation. Amortization of Deferred Stock Based Compensation Amortization of deferred stock-based compensation Release of restricted stock units. Release of Restricted Stock Units Release of restricted stock units Other Comprehensive Income (Loss), Net of Tax [Abstract] Comprehensive loss: Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax Change in unrealized gain/(loss) on investments Other Comprehensive Income (Loss), Net of Tax Total comprehensive loss Statement, Scenario [Axis] Scenario Unspecified [Domain] Scenario, Unspecified [Domain] Vesting of early exercised stock options. Vesting Of Early Exercised Stock Options [Member] Vesting of Early Exercised Stock Options [Member] Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Lower Range Limit Exercise of stock options, minimum price per share Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Upper Range Limit Exercise of stock options, maximum price per share Issuance of warrant to purchase stock to investors per share. Issuance of Warrant to Purchase Stock to Investors per Share Issuance of warrant to purchase stock to investors per share Consolidated Statements Of Cash Flows [Abstract] Operating activities Adjustments to reconcile net loss to cash (used in)/provided by operating activities: Adjustments to reconcile net loss to cash (used in) provided by operating activities: Depreciation Depreciation, Total Amortization/accretion of debt issuance costs and debt discount Amortization of debt issuance costs and accretion of debt discount Amortization of Financing Costs and Discounts, Total Amortization of investment premiums Amortization of investment premiums Stock based compensation expense Stock-based compensation Share-based Compensation, Total Disposal of property and equipment Gain on disposal of property and equipment Gain (Loss) on Sale of Property Plant Equipment, Total Changes in operating assets and liabilities: Increase (Decrease) in Restricted Cash for Operating Activities Restricted cash Restricted cash Trade receivables Trade receivables The net change during the reporting period in amount due within one year (or one business cycle) from collaboration partners for the credit sale of goods and services, royalties and milestone achievement. Increase Decrease In Receivable From Collaboration Partner Receivable from collaboration partner Receivable from collaboration partner IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets Prepaid expenses and other current assets Prepaid expenses and other current assets Increase (Decrease) in Prepaid, Deferred Expense and Other Assets, Total Increase Decrease In Inventories Inventories Inventories Increase (Decrease) in Inventories, Total Increase Decrease In Accounts Payable Accounts payable Accounts payable Increase (Decrease) in Accounts Payable, Total Increase (Decrease) in Accrued Salaries Accrued compensation The net change during the reporting period of obligations incurred and payable, pertaining to research and development costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Increase Decrease In Accrued Research And Development Accrued research and development Accrued research and development Accrued research and development The net change during the reporting period of license fees due to third parties. Increase Decrease in Accrued license fees Accrued license fees Accrued interest payable on long-term obligations Deferred product revenue Deferred product revenue, net The net change during the reporting period for amounts due from collaboration partners, for goods or services that have been delivered or sold under the terms of an collaboration agreement. Increase Decrease In Deferred Collaborative Revenue Deferred CollaboDeferred collaborative revenue Deferred collaboration revenue Increase (Decrease) in Other Noncurrent Liabilities Other long-term liabilities Increase DecreaseIn Other Accrued Liabilities Other accrued expenses Net cash (used in)/provided by operating activities Net cash (used in) provided by operating activities Investing activities Payments to Acquire Available-for-sale Securities, Debt Purchases of short-term investments Purchases of short-term investments Proceeds from Sale and Maturity of Available-for-sale Securities Proceeds from maturities of short-term investments Proceeds from Sale and Maturity of Available-for-sale Securities, Total Proceeds from maturities of short-term investments Proceeds from sales of short-term investments Increase (Decrease) in Restricted Cash Change in restricted cash Change in restricted cash Increase (Decrease) in Restricted Cash, Total Purchases of property and equipment Purchases of property and equipment Payments to Acquire Property, Plant, and Equipment, Total Net cash (used in)/provided by investing activities Net cash provided by (used in) investing activities Financing activities Repayment of notes payable Repayment of notes payable Proceeds from issuance of long term obligations Proceeds from issuance of long-term obligations Proceeds from Issuance of Long-term Debt, Total Payments of Debt Issuance Costs Payment of debt issuance costs Payments of Long term obligation issuance costs Capitalization of debt issuance costs Proceeds from Issuance of Warrants Proceeds from issuance of warrants Proceeds from issuance of common stock Net cash provided by/(used in) financing activities Net cash provided by (used in) financing activities Net cash provided by (used in) financing activities Net (decrease)/increase in cash and cash equivalents Net increase (decrease) in cash and cash equivalents Supplemental cash flow information Cash paid for interest Interest Paid, Net, Total Non cash financing activities [abstract]. Non Cash Financing Activities [Abstract] Non-cash financing activities Contingent put option liability. Contingent Put Option Liability Contingent put option liability Warrants issued in connection with private equity placement and debt financing. Warrants Issued in Connection with Private Equity Placement and Debt Financing Warrants issued in connection with private equity placement and debt financing The Company [Abstract] Organization Consolidation And Presentation Of Financial Statements Disclosure Text Block The Company Summary Of Significant Accounting Policies [Abstract] Significant Accounting Policies Text Block Summary Of Significant Accounting Policies Cash And Cash Equivalents And Short-Term Investments [Abstract] Cash and cash equivalents and short-term investments. Cash and Cash Equivalents and Short Term Investments [Text Block] Cash And Cash Equivalents And Short-Term Investments Fair Value Measurements [Abstract] Fair Value Measurement Inputs DisclosureTextBlock Fair Value Measurements Inventories [Abstract] Inventory Disclosure Text Block Inventories Property And Equipment [Abstract] Property, Plant and Equipment Disclosure [Text Block] Property And Equipment Long-Term Obligations [Abstract] Long Term Debt Text Block Long-Term Obligations Commitments And Contingencies [Abstract] Commitments And ContingenciesDisclosure Text Block Commitments And Contingencies Commitments and Contingencies Restructuring [Abstract] Restructuring and Related Activities Disclosure [Text Block] Restructuring License Agreements License Agreements [Abstract] License Agreements License agreements. License Agreements Text Block License Agreements Stockholders' Equity [Abstract] Stockholders Equity Note DisclosureText Block Stockholders' Equity Income Taxes [Abstract] Income Tax Disclosure [Text Block] Income Taxes Subsequent Events [Abstract] Subsequent Events [Text Block] Subsequent Events Quarterly Information [Abstract] Quarterly Financial Information [Text Block] Quarterly Information