Consolidated Statements Of Operations (USD $) In Thousands, except Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Consolidated Statements Of Operations [Abstract]
Net product revenue	$ 2,625	$ 688
Collaboration revenue	8,878	7,578	2,006
Total revenues	11,503	8,266	2,006
Operating expenses:
Cost of goods sold	685	541
Research and development	13,566	11,151	11,235
Selling, general and administrative	36,408	36,383	12,420
Total operating expenses	50,659	48,075	23,655
Loss from operations	(39,156)	(39,809)	(21,649)
Interest income	79	98	89
Interest expense	(10,405)	(5,413)	(276)
Other income (expense), net	(63)	608	(31)
Net loss	$ (49,545)	$ (44,516)	$ (21,867)
Basic and diluted net loss per share	$ (2.15)	$ (2.51)	$ (1.24)
Shares used to compute basic and diluted net loss per share	23,011,015	17,768,881	17,610,796