Commitments and Contingencies - Earn Out Payments (Details) $ in Thousands	Apr. 12, 2021 USD ($)
Commercial Global License Agreements, AR101
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
License agreement, milestone, maximum earn-out, cash and common stock	$ 67,500
Commercial Global License Agreement, Denovo Biopharma LLC, AR101
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
License agreement, license option fee	600
License agreement, escalating royalties, maximum	101,700
Commercial Global License Agreement, Johns Hopkins University, AR101
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
License agreement, minimum annual royalties, low end of range	$ 20
License agreement, royalties, percentage of net product sales (as a percent)	3.00%
License agreement, royalties, achievement of certain regulatory and commercial milestones, maximum	$ 1,600