<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<headerData>
<submissionType>144</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001385266</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>
</filerInfo>
</headerData>
<formData>
<issuerInfo>
<issuerCik>0000883237</issuerCik>
<issuerName>VIRTUS INVESTMENT PARTNERS, INC.</issuerName>
<secFileNumber>001-10994</secFileNumber>
<issuerAddress>
<street1 xmlns="http://www.sec.gov/edgar/common">ONE FINANCIAL PLAZA</street1>
<street2 xmlns="http://www.sec.gov/edgar/common">26TH FLOOR</street2>
<city xmlns="http://www.sec.gov/edgar/common">HARTFORD</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">CT</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">06103</zipCode>
</issuerAddress>
<issuerContactPhone>860-263-4707</issuerContactPhone>
<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MORRIS W HOWARD</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
<relationshipsToIssuer>
<relationshipToIssuer>Director</relationshipToIssuer>
</relationshipsToIssuer>
</issuerInfo>
<securitiesInformation>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<brokerOrMarketmakerDetails>
<name>Ameriprise</name>
<address>
<street1 xmlns="http://www.sec.gov/edgar/common">39400 Woodward Avenue</street1>
<city xmlns="http://www.sec.gov/edgar/common">Bloomfield Hills</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">MI</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">48304</zipCode>
</address>
</brokerOrMarketmakerDetails>
<noOfUnitsSold>435</noOfUnitsSold>
<aggregateMarketValue>64123.35</aggregateMarketValue>
<noOfUnitsOutstanding>6622690</noOfUnitsOutstanding>
<approxSaleDate>09/15/2026</approxSaleDate>
<securitiesExchangeName>NYSE</securitiesExchangeName>
</securitiesInformation>
<securitiesToBeSold>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<acquiredDate>03/17/2022</acquiredDate>
<natureOfAcquisitionTransaction>Open Market Purchase</natureOfAcquisitionTransaction>
<nameOfPersonfromWhomAcquired>Virtus Investment Partners, Inc.</nameOfPersonfromWhomAcquired>
<isGiftTransaction>N</isGiftTransaction>
<amountOfSecuritiesAcquired>435</amountOfSecuritiesAcquired>
<paymentDate>03/17/2022</paymentDate>
<natureOfPayment>Personal Payment</natureOfPayment>
</securitiesToBeSold>
<nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
<remarks>The selling entity of the 435 shares of Common Stock identified in Table I to be sold is The Prairie &amp; Tireman Group LLC. W. Howard Morris is the president and chief investment officer of The Prairie &amp; Tireman Group LLC.</remarks>
<noticeSignature>
<noticeDate>09/15/2026</noticeDate>
<signature>/s/ Ronnie D. Kryjak, Attorney-in-Fact</signature>
</noticeSignature>
</formData>
</edgarSubmission>
