X0303 4 2010-02-26 1 0000875622 BIOSPECIFICS TECHNOLOGIES CORP BSTC 0001346824 RA CAPITAL MANAGEMENT, LLC C/O RA CAPITAL MANAGEMENT, LLC 20 PARK PLAZA, SUITE 905 BOSTON MA 02116 0 0 1 0 0001384859 Kolchinsky Peter C/O RA CAPITAL MANAGEMENT, LLC 20 PARK PLAZA, SUITE 905 BOSTON MA 02116 0 0 1 0 0001315082 RA Capital Healthcare Fund LP C/O RA CAPITAL MANAGEMENT, LLC 20 PARK PLAZA, SUITE 905 BOSTON MA 02116 0 0 1 0 Common Stock 2010-02-26 4 S 0 10000 28.83 D 626462 I see footnote These shares represent 523,808 shares held by RA Capital Healthcare Fund, L.P. ("Fund I") and 102,654 shares held by Blackwell Partners, LLC ("Blackwell"). RA Capital Management, LLC (the "Adviser") is the general partner of Fund I and the investment adviser of Blackwell. Peter Kolchinsky is the sole manager of the Adviser. Each of the Reporting Persons disclaims beneficial ownership of any shares of the above names Issuer reported herein, except to the extent of his or its pecuniary interest therein. Peter Kolchinsky, Manager of RA Capital Management, LLC 2010-02-26 Peter Kolchinsky 2010-02-26 Peter Kolchinsky, Manager of RA Capital Management, LLC, the General Partner of RA Capital Healthcare Fund, L.P. 2010-02-26