X0306 4 2019-02-07 0 0001383701 Conatus Pharmaceuticals Inc. CNAT 0001324466 Mento Steven J C/O CONATUS PHARMACEUTICALS INC. 16745 WEST BERNARDO DRIVE, SUITE 200 SAN DIEGO CA 92127 1 1 0 0 President, CEO & Director Stock Option (Right to Buy) 2.00 2019-02-07 4 A 0 350000 0.00 A 2029-02-06 Common Stock 350000 350000 D The option was granted on February 7, 2019. 25% of the total number of shares of common stock subject to the option will vest on February 6, 2020, and 1/48th of the total number of shares of common stock subject to the option will vest monthly thereafter, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date. /s/ Michelle L. Vandertie, Attorney-in-Fact for Steven J. Mento 2019-02-11