X0306 4 2016-06-23 0 0001383701 Conatus Pharmaceuticals Inc. CNAT 0001580680 Van Wart Harold C/O CONATUS PHARMACEUTICALS INC. 16745 WEST BERNARDO DRIVE, SUITE 200 SAN DIEGO CA 92127 1 0 0 0 Stock Option (Right to Buy) 2.13 2016-06-23 4 A 0 20000 0.00 A 2026-06-22 Common Stock 20000 20000 D The shares subject to this option become exercisable as the shares vest. The entire number of shares subject to this option becomes fully vested and exercisable on the first anniversary of the grant date, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date. /s/ Charles J. Cashion, Attorney-in-Fact for Harold Van Wart 2016-06-24