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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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<SEC-DOCUMENT>9999999995-07-001465.txt : 20070426
<SEC-HEADER>9999999995-07-001465.hdr.sgml : 20070426
<ACCEPTANCE-DATETIME>20070426001519
ACCESSION NUMBER:		9999999995-07-001465
CONFORMED SUBMISSION TYPE:	EFFECT
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20070425
DATE AS OF CHANGE:		20070426
EFFECTIVENESS DATE:		20070425

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Orexigen Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001382911
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				651178822
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		EFFECT
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-139496
		FILM NUMBER:		07789083

	BUSINESS ADDRESS:	
		STREET 1:		12481 HIGH BLUFF DRIVE, SUITE 160
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130
		BUSINESS PHONE:		(858) 436-8600

	MAIL ADDRESS:	
		STREET 1:		12481 HIGH BLUFF DRIVE, SUITE 160
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130
</SEC-HEADER>
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<TYPE>EFFECT
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0101</schemaVersion>

    <submissionType>EFFECT</submissionType>

    <act>33</act>

    <testOrLive>LIVE</testOrLive>

    <effectiveData>
        <finalEffectivenessDispDate>2007-04-25</finalEffectivenessDispDate>
        <finalEffectivenessDispTime>16:30:00</finalEffectivenessDispTime>
        <form>S-1</form>
        <filer>
            <cik>0001382911</cik>
            <entityName>Orexigen Therapeutics, Inc.</entityName>
            <fileNumber>333-139496</fileNumber>
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</XML>
</TEXT>
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