X0306 4 2015-12-01 0 0001382911 Orexigen Therapeutics, Inc. OREX 0001659824 Lynch Thomas P. 3344 NORTH TORREY PINES COURT SUITE 200 LA JOLLA CA 92037 0 1 0 0 EVP. General Counsel & Sec. Stock Option (right to buy) 2.29 2015-12-01 4 A 0 350000 A 2025-11-30 Common Stock 350000 350000 D 25% of the shares of stock subject to the option (rounded down to the next whole number of shares) shall vest on 12/01/2016 and 1/48th of the shares of stock subject to the option (rounded down to the next whole number of shares) shall vest on the same day of each month thereafter, so that all of the shares of stock subject to the option shall be vested on 12/01/2019, subject to the Reporting Person's continued service relationship (whether as an employee, director or consultant) with the Issuer or any parent or subsidiary of the Issuer on each such date. Not Applicable Joseph P. Hagan, Attorney-in-Fact for Thomas P. Lynch 2015-12-02