X0306 4 2013-02-15 0 0001382911 Orexigen Therapeutics, Inc. OREX 0001403571 Turner Heather D C/O OREXIGEN THERAPEUTICS, INC. 3344 N. TORREY PINES COURT, SUITE 200 LA JOLLA CA 92037 0 1 0 0 SVP, Gen. Counsel & Secretary Stock Option (right to buy) 5.69 2013-02-15 4 A 0 240000 A 2023-02-14 Common Stock 240000 240000 D 1/48th of the shares of stock subject to the option (rounded down to the next whole number of shares) shall vest on the same day of each month following 2/15/2013, so that all of the shares of the stock subject to the option shall be vested on 2/15/2017, subject to the reporting person's continued service relationship (whether as an employee, director or consultant) with the Company or any parent or subsidiary on each such date. Not applicable. /s/ Heather D. Turner 2013-02-19