X0303 4 2009-08-14 0001382911 Orexigen Therapeutics, Inc. OREX 0001207786 DOVEY BRIAN H C/O DOMAIN ASSOCIATES, LLC ONE PALMER SQUARE PRINCETON NJ 08542 1 0 1 0 Common Stock 2009-08-14 4 P 0 25785 8.00 A 1655573 I By Domain Partners VII, L.P. Common Stock 2009-08-14 4 P 0 440 8.00 A 28253 I By DP VII Associates, L.P. Common Stock 2009-08-17 4 P 0 62141 7.64 A 1717714 I By Domain Partners VII, L.P. Common Stock 2009-08-17 4 P 0 1060 7.64 A 29313 I By DP VII Associates, L.P. The Reporting Person is a Managing Member of One Palmer Square Associates VII, LLC, which is the sole general partner of Domain Partners VII, L.P. and DP VII Associates, L.P. Pursuant to Instruction 4(b)(iv) of Form 4, the Reporting Person has elected to report as indirectly beneficially owned the entire number of securities beneficially owned by each such entity. The Reporting Person disclaims beneficial ownership of any securities, and any proceeds thereof, that exceed his or her pecuniary interest therein and/or that are not actually distributed to him or her. The Reporting Person also directly beneficially owns 20,128 shares of Common Stock and indirectly beneficially owns (i) 1,963 shares held by Domain Associates, LLC; (ii) 3,543,832 shares held by Domain Partners V, L.P.; and (iii) 83,975 shares held by DP V Associates, L.P. The Reporting Person is a Managing Member of Domain Associates, LLC and a Managing Member of One Palmer Square Associates V, LLC, which is the sole general partner of Domain Partners V, L.P. and DP V Associates, L.P. Pursuant to Instruction 4(b)(iv) of Form 4, the Reporting Person has elected to report as indirectly beneficially owned the entire number of securities beneficially owned by each such entity. The Reporting Person disclaims beneficial ownership of any securities, and any proceeds thereof, that exceed his or her pecuniary interest therein and/or that are not actually distributed to him or her. /s/Kathleen K. Schoemaker, Attorney-in-Fact 2009-08-18