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Income Taxes - Effective Income Tax Rate Reconciliation (Details)
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Income Tax Disclosure [Abstract]      
U.S. federal income tax at statutory rate 21.00% 21.00% 21.00%
State taxes (net of federal benefit) 4.89% 9.06% 25.23%
Stock-based compensation (2.53%) 14.88% 69.14%
Permanent differences (0.14%) (0.12%) (1.03%)
Federal research and development credit 1.38% 5.41% 20.42%
Change in valuation allowance (21.29%) (41.89%) (132.88%)
Other 0.20% (1.62%) 1.32%
Acquisition costs (0.01%) (1.44%) 0.00%
Extinguishment of convertible notes 0.00% 0.00% (3.20%)
Expiration of tax attribute carryforwards (3.53%) 0.00% 0.00%
Effective income tax rate (0.03%) 5.28% 0.00%