Income Taxes Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Income Tax Disclosure [Abstract]

Schedule of Deferred Tax Assets and Liabilities

The following table represents the significant components of our deferred tax assets and liabilities for the periods presented:

	December 31,
	2021		2020
Deferred income tax assets
Net operating loss carryforwards	$	143,917	$	57,763
Business interest limitation carryforwards	35,234		—
Tax credit carryforwards	18,828		12,422
Stock-based compensation	7,117		6,011
Compensation accruals	7,606		7,026
Lease liabilities	17,396		17,540
Accruals and reserves	4,542		1,004
Fixed assets	3,887		1,075
Gross deferred income tax assets	238,527		102,841
Valuation allowance	(176,872)		(44,307)
Total deferred income tax assets, net of valuation allowance	61,655		58,534
Deferred income tax liabilities
Intangible assets	(48,250)		(514)
Convertible senior notes	—		(45,616)
Right-of-use assets	(13,465)		(12,404)
Other	(1,141)		—
Total deferred income tax liabilities	(62,856)		(58,534)
Net deferred income tax assets and liabilities	$	(1,201)	$	—

Summary of Operating Loss Carryforwards

The following table represents our net operating loss ("NOL") carryforwards as of December 31, 2021 and 2020:

	December 31,
	2021		2020
Federal	$	611,296	$	227,751
Various states	18,777		12,576
Foreign	3,213		2,050

Schedule of Effective Income Tax Rate Reconciliation

The following table is a reconciliation of the U.S. federal income tax at statutory rate to our effective income tax rate:

	December 31,
	2021		2020		2019
U.S. federal income tax at statutory rate	21.00	%	21.00	%	21.00	%
State taxes (net of federal benefit)	9.06		25.23		4.71
Stock-based compensation	14.88		69.14		1.20
Permanent differences	(0.12)		(1.03)		(0.97)
Federal research and development credit	5.41		20.42		2.45
Change in valuation allowance	(41.89)		(132.88)		(29.73)
Other	(1.62)		1.32		1.34
Acquisition costs	(1.44)		—		—
Extinguishment of 2023 Notes	—		(3.20)		—
Effective income tax rate	5.28	%	—	%	—	%

Schedule of Components of Income Tax Benefit

The following table summarizes the components of our income tax benefit for the periods presented:

	December 31,
	2021		2020		2019
Current income tax expense:
U.S. - State	$	1,215	$	—	$	—
Total current income tax expense	1,215		—		—
Deferred income tax benefit:
U.S. - State	(7,322)		—		—
Total deferred income tax benefit	(7,322)		—		—
Total income tax benefit	$	(6,107)	$	—	$	—

Schedule of Unrecognized Tax Benefits Roll Forward

The following table summarizes the activity related to unrecognized tax benefits:

	December 31,
	2021		2020
Unrecognized benefit—beginning of year	$	3,105	$	2,159
Gross decreases—prior year tax positions	32		—
Gross increases—current year tax positions	1,555		946
Unrecognized benefit—end of year	$	4,692	$	3,105