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Income Taxes - Effective Income Tax Rate Reconciliation (Details)
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Income Tax Disclosure [Abstract]      
U.S. federal income tax at statutory rate 34.00% 34.00% 34.00%
State taxes (net of federal benefit) 2.40% 2.49% 3.86%
Permanent differences (15.03%) (8.21%) (2.94%)
Federal research and development credit 7.08% 2.06% 2.42%
Change in valuation allowance (27.79%) (30.19%) (37.36%)
Nondeductible expenses and others (0.66%) (0.15%) 0.02%
Change in valuation allowance for Tax Act impact 84.37% 0.00% 0.00%
Change in deferred balance before valuation allowance for Tax Reform impact (84.37%) 0.00% 0.00%
Effective income tax rate 0.00% 0.00% 0.00%