SCHEDULE 13G/A 0000921895-24-000728 0001380585 XXXXXXXX LIVE 2 Common Stock, par value $0.0001 per share 06/30/2025 0001683553 SPRUCE BIOSCIENCES, INC. 85209E109 611 GATEWAY BOULEVARD, SUITE 740 SOUTH SAN FRANCISCO CA 94080 Rule 13d-1(c) Radoff Family Foundation TX 0.00 0.00 0.00 0.00 0.00 N 0 CO Radoff Bradley Louis X1 0.00 0.00 0.00 0.00 0.00 N 0 IN SPRUCE BIOSCIENCES, INC. 611 GATEWAY BOULEVARD, SUITE 740, SOUTH SAN FRANCISCO, CALIFORNIA 94080 This statement is filed by The Radoff Family Foundation, a Texas non-profit corporation ("Radoff Foundation"), and Bradley L. Radoff. Each of the foregoing is referred to as a "Reporting Person" and collectively as the "Reporting Persons." The address of the principal office of each of the Reporting Persons is 2727 Kirby Drive, Unit 29L, Houston, Texas 77098. Radoff Foundation is organized under the laws of the State of Texas and Mr. Radoff is a citizen of the United States of America. Y As of the close of business on June 30, 2025, the Reporting Persons no longer beneficially owned any securities of the Issuer. As of the close of business on June 30, 2025, the Reporting Persons no longer beneficially owned any securities of the Issuer. See Cover Pages Items 5-9. See Cover Pages Items 5-9. See Cover Pages Items 5-9. See Cover Pages Items 5-9. N Y Y Y N See Exhibit 99.1 to the Schedule 13G filed by the Reporting Persons on November 12, 2024. Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Radoff Family Foundation /s/ Bradley L. Radoff 08/13/2025 Radoff Bradley Louis /s/ Bradley L. Radoff 08/13/2025