X0306 4 2022-05-23 0001380106 RAPID MICRO BIOSYSTEMS, INC. RPID 0001619884 Hirsch David C/O LONGITUDE CAPITAL PARTNERS II, LLC 2740 SAND HILL ROAD, SECOND FLOOR MENLO PARK CA 94025 1 1 Stock Option (Right to Buy) 4.50 2022-05-23 4 A 0 12500 0 A 2032-05-22 Class A Common Stock 12500 12500 D The option shall vest and become exercisable in full on the earlier of (i) the first anniversary of the Grant Date, or (ii) the day immediately prior to the date of the next annual meeting of the stockholders of the Company provided that the Reporting Person remains in continuous service on such vesting date. /s/ Jonathan Paris, Attorney-in-Fact for David Hirsch 2022-06-10