The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ARCOSA INC COM 039653100 955 27,923 SH   SOLE   0 0 27,923
BERKSHIRE HATHAWAY INC DEL CL A 084670108 31,183 100 SH   SOLE   0 0 100
BIOCRYST PHARMACEUTICALS COM 09058V103 1,375 479,902 SH   SOLE   0 0 479,902
COCRYSTAL PHARMA INC COM PAR 19188J300 312 152,916 SH   SOLE   0 0 152,916
EIDOS THERAPEUTICS INC COM 28249H104 2,437 67,753 SH   SOLE   0 0 67,753
GENOMIC HEALTH INC COM 37244C101 645 9,506 SH   SOLE   0 0 9,506
HERON THERAPEUTICS INC COM 427746102 925 49,974 SH   SOLE   0 0 49,974
INFLARX NV COM N44821101 91 36,818 SH   SOLE   0 0 36,818
MEIRAGTX HOLDINGS PLC COM G59665102 1,295 81,176 SH   SOLE   0 0 81,176
MYOVANT SCIENCES LTD COM G637AM102 762 146,475 SH   SOLE   0 0 146,475
ORCHARD THERAPEUTICS PLC ADS 68570P101 1,291 108,692 SH   SOLE   0 0 108,692
RA PHARMACEUTICALS INC COM 74933V108 1,412 59,690 SH   SOLE   0 0 59,690
RETROPHIN INC COM 761299106 895 77,180 SH   SOLE   0 0 77,180
RHYTHM PHARMACEUTICALS INC COM 76243J105 1,551 71,856 SH   SOLE   0 0 71,856
SPDR S&P 500 ETF TR TR UNIT 78462F103 280 942 SH   SOLE   0 0 942
SUMMIT MIDSTREAM PARTNERS LP COM UNIT LTD 866142102 342 70,456 SH   SOLE   0 0 70,456
SYNTHORX INC COM 87167A103 2,362 145,150 SH   SOLE   0 0 145,150
WAVE LIFE SCIENCES LTD SHS Y95308105 1,606 78,212 SH   SOLE   0 0 78,212
ZOGENIX INC COM NEW 98978L204 997 24,890 SH   SOLE   0 0 24,890