X0306 4 2018-05-30 0 0001515673 Ultragenyx Pharmaceutical Inc. RARE 0001377202 Sharp Shalini C/O ULTRAGENYX PHARMACEUTICAL INC. 60 LEVERONI COURT NOVATO CA 94949 0 1 0 0 CFO & Executive Vice President Common Stock 2018-05-30 4 M 0 6500 0.815 A 70174 D Common Stock 2018-05-30 4 S 0 13000 70.167 D 57174 D Stock Option (Right to Buy) 0.815 2018-05-30 4 M 0 6500 0.00 D 2022-08-01 Common Stock 6500 25663 D The sales reported on this Form 4 were effected pursuant to a trading plan adopted by the Reporting Person pursuant to Rule 10b5-1 under the Securities Exchange Act of 1934, as amended. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $70.00 to $70.86 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions. 1/4th of the option vested one year from May 21, 2012 and then 1/48th monthly thereafter. /s/ Ruben A. Garcia, attorney-in-fact 2018-05-30