144 0001398940 XXXXXXXX LIVE 0001377121 Protagonist Therapeutics, Inc 001-37852 7707 GATEWAY BLVD., SUITE 140 NEWARK CA 94560-1160 (510) 474-0170 MOLINA ARTURO MD Officer Common Morgan Stanley Smith Barney LLC Executive Services

200 W Civic Center Dr - 4th Floor Sandy UT 84070

30514 1678270.00 61400000 03/13/2025 NASDAQ COMMON 03/13/2025 STOCK OPTION EXERCISE ISSUER N 30514 03/13/2025 COMPENSATION N ARTURO MOLINA

7707 GATEWAY BLVD STE 140, NEWARK CA 94560

RESTRICTED STOCK 01/16/2025 3640 133017.95 03/13/2025 /s/ Arturo Molina