Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Cash Flows from Operating Activities
Net loss	$ (93,199)	$ (88,644)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation	18,690	11,371
Operating lease right-of-use asset amortization	1,751	1,378
Net amortization of premium on marketable securities	365	1,321
Depreciation	778	578
Changes in operating assets and liabilities:
Research and development tax incentive receivable	2,719	(854)
Receivable from collaboration partner - related party	1,441	(212)
Prepaid expenses and other assets	413	(2,632)
Accounts payable	3,121	(2,285)
Payable to collaboration partner - related party	(867)	(1,611)
Accrued expenses and other payables	(8,127)	14,393
Deferred revenue - related party	(1,601)	(12,236)
Operating lease liability	(1,986)	(1,493)
Net cash used in operating activities	(76,502)	(80,926)
Cash Flows from Investing Activities
Purchase of marketable securities	(134,279)	(255,902)
Proceeds from maturities of marketable securities	222,537	213,080
Purchases of property and equipment	(725)	(905)
Net cash provided by (used in) investing activities	87,533	(43,727)
Cash Flows from Financing Activities
Proceeds from public offering of common stock, net of issuance costs	14,553	123,995
Proceeds from issuance of common stock upon exercise of stock options and purchases under employee stock purchase plan	3,895	3,944
Tax withholding payments related to net settlement of restricted stock units	(188)	(189)
Issuance costs related to prior period common stock offering	25
Net cash provided by financing activities	18,285	127,750
Effect of exchange rate changes on cash, cash equivalents and restricted cash	(165)	(148)
Net increase in cash, cash equivalents and restricted cash	29,151	2,949
Cash, cash equivalents and restricted cash, beginning of period	123,890	117,818
Cash, cash equivalents and restricted cash, end of period	153,041	120,767
Supplemental Disclosure of Non-Cash Financing and Investing Information:
Purchases of property and equipment in accounts payable and accrued liabilities	$ 61	24
Public Offering | Accrued liabilities and other payables
Supplemental Disclosure of Non-Cash Financing and Investing Information:
Issuance costs related to common stock offering		$ 191