Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Income Taxes

Schedule of domestic and foreign components of net loss

The following table presents domestic and foreign components of net loss before income taxes (in thousands):

	Year Ended December 31,
	2021		2020		2019
Domestic	$	(125,797)	$	(71,073)	$	(72,271)
Foreign		246		6,228		(5,607)
Total net loss before taxes	$	(125,551)	$	(64,845)	$	(77,878)

Schedule of federal, state and foreign of the income tax expense (benefit)

	Year Ended December 31,
	2021		2020		2019
Current:
Federal	$	—	$	—	$	—
State		—		—		—
Foreign		—		(88)		84
Total current tax (benefit) expense		—		(88)		84
Deferred:
Federal		—		—		—
State		—		—		—
Foreign		—		1,393		(775)
Total deferred tax expense (benefit)		—		1,393		(775)
Total income tax expense (benefit)	$	—	$	1,305	$	(691)

Schedule of provision differences from federal statutory rate

	Year Ended December 31,
	2021		2020		2019
Federal statutory income tax rate	21.0	%	21.0	%	21.0	%
State taxes, net of federal benefit	1.9		1.9		1.2
Research and development credits	4.3		6.5		4.3
Foreign tax rate difference	—		(0.9)		0.7
Change in valuation allowance	(28.0)		(34.3)		(23.8)
Other	0.8		3.8		(2.5)
(Provision) benefit for income taxes	—	%	(2.0)	%	0.9	%

Schedule of components of deferred tax assets

The components of the deferred tax assets are as follows (in thousands):

	December 31,
	2021		2020
Deferred tax assets:
Net operating loss carryforwards	$	75,649	$	50,272
Depreciation and amortization		1,153		1,237
Accruals/other		5,716		5,332
Operating lease liability		1,230		1,252
Research and development and foreign credits		21,197		14,856
Total deferred tax assets		104,945		72,949
Deferred tax liabilities:
Operating right-of-use asset		(1,037)		(1,040)
Total deferred tax liabilities		(1,037)		(1,040)
Valuation allowance		(103,908)		(71,909)
Net deferred tax assets	$	—	$	—

Schedule of reconciliation of beginning and ending unrecognized tax benefits

A reconciliation of the beginning and ending amount of unrecognized tax benefits is as follows (in thousands):

	Year Ended December 31,
	2021		2020		2019
Balance at beginning of year	$	19,885	$	16,631	$	9,466
(Decreases) increases based on tax positions related to prior years		—		(3,799)		184
Increases based on tax positions related to current year		13,274		7,053		6,981
Balance at end of year	$	33,159	$	19,885	$	16,631